Results 271 to 280 of about 57,794 (383)

Core targets of bisphenol A in cervical cancer revealed by network toxicology and molecular docking. [PDF]

Medicine (Baltimore)
Li Y, Zhang W, Tang L, Zhu Y, Dong H, Yang L, Zhao Y.   +6 more
europepmc   +1 more source

Integrated WGCNA of lncRNA-mRNA Networks Identifies Novel Hub Genes and Potential Therapeutic Agents for Liver Cirrhosis via Molecular Docking Validation. [PDF]

Int J Mol Sci
Wu T, Jin J, Yang Y, Sui J, Zhou Y, Yuan H.   +5 more
europepmc   +1 more source

Comprehensive analysis of immunogenic cell death-related gene and construction of prediction model based on WGCNA and multiple machine learning in severe COVID-19 [PDF]

Chunyu Li, Ke Wu, Rui Yang, Minghua Liao, Jun Li, Qian Zhu, Jiayi Zhang, Xianming Zhang   +7 more
openalex   +1 more source

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, Volume 46, Issue 4, Page 1076-1082, April 2026.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Comprehensive analysis of molecular immunological characteristics and potential biomarkers in brucellosis. [PDF]

Front Immunol
Wang R, He J, Li X, Shi Y, Duan H, Ding H.   +5 more
europepmc   +1 more source

Immune-related inflammatory gene in hypertrophic scar: prognostic and molecular mechanisms via integrated machine learning-WGCNA analysis [PDF]

Yufang Liu, Huiling Li, Chunfeng Zhao, Xin Wang   +3 more
openalex   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

H1FX as a novel biomarker linking pan-apoptosis to immune dysregulation in allergic rhinitis. [PDF]

Eur J Med Res
Liang Y, Mai Z, Li R, Liu Y, Zhan J.
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, Volume 13, Issue 17, 23 March 2026.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

iModMix: integrative module analysis for multi-omics data. [PDF]

Bioinformatics
Narváez-Bandera I, Lui A, Mekonnen YA, Rubio V, Takyi A, Sulman N, Wilson C, Ackerman HD, Ospina OE, Gonzalez-Calderon G, Flores ER, Li Q, Chen A, Fridley BL, Stewart PA.   +14 more
europepmc   +1 more source