Results 101 to 110 of about 6,982,631 (374)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transdiagnostic Role of Glutamate and White Matter Damage in Neuropsychiatric Disorders: A Systematic Review [PDF]

, 2022
Ines Luttenbacher, Angela Philips, Reza Kazemi, Abed L. Hadipour, Isha Sanghvi, Julián Martínez, Maheen M. Adamson   +6 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Lnc_011797 promotes ferroptosis and aggravates white matter lesions

Neural Regeneration Research
Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, the mechanisms and regulatory pathways involved in ferroptosis within white matter lesions remain unclear.
Xiang Xu, Yu Sun, Xiaoyan Zhu, Shiyin Ma, Jin Wei, Chang He, Jing Chen, Xudong Pan   +7 more
doaj   +1 more source

Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging

Frontiers in Human Neuroscience, 2012
Previous neuroimaging research indicates that white matter injury and integrity, measured respectively by white matter hyperintensities (WMH) and fractional anisotropy (FA) obtained from diffusion tensor imaging, differ with aging and cerebrovascular ...
Samuel Neal Lockhart, Samuel Neal Lockhart, Samuel Neal Lockhart, Adriane B. V. Mayda, Adriane B. V. Mayda, Adriane B. V. Mayda, Alexandra E. Roach, Alexandra E. Roach, Alexandra E. Roach, Evan eFletcher, Evan eFletcher, Owen eCarmichael, Owen eCarmichael, Pauline eMaillard, Pauline eMaillard, Christopher G. Schwarz, Christopher G. Schwarz, Andrew P. Yonelinas, Andrew P. Yonelinas, Charan eRanganath, Charan eRanganath, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli   +24 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

White versus gray matter function as seen on neuropsychological testing following bone marrow transplant for acute leukemia in childhood

Neuropsychiatric Disease and Treatment, 2008
Fiona S Anderson1, Alicia S Kunin-Batson1, Joanna L Perkins2, K Scott Baker31Divisions of Pediatric Clinical Neuroscience; 2Department of Pediatric Hematology/Oncology, Children’s Hospitals and Clinics, Minneapolis, MN, USA and 3Hematology ...
Fiona S Anderson, Alicia S Kunin-Batson, Joanna L Perkins, K Scott Baker   +3 more
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Finite bounded expanding white hole universe without dark matter

, 2007
The solution of Einstein's field equations in Cosmological General Relativity (CGR), where the Galaxy is at the center of a finite yet bounded spherically symmetrical isotropic gravitational field, is identical with the unbounded solution.
A.G. Riess, F.J. Oliveira, J. Smoller, J.G. Hartnett, J.G. Hartnett, J.G. Hartnett, John G. Hartnett, M. Carmeli, M. Carmeli, M. Carmeli, P. Astier, R.A. Knop, S. Behar, W.W. Gibbs   +13 more
core   +1 more source

Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury [PDF]

, 2022
E. J. Marijke Achterberg, Ralf J. van Oldeniel, Erik van Tilborg, Jeroen P. H. Verharen, Cora H. Nijboer, Louk J. M. J. Vanderschuren   +5 more
openalex   +1 more source