Results 111 to 120 of about 6,982,631 (374)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

General circular velocity relation of a test particle in a 3D gravitational potential: application to the rotation curves analysis and total mass determination of UGC 8490 and UGC 9753

open access: yes, 2018
In this paper we derive a novel circular velocity relation for a test particle in a 3D gravitational potential applicable to every system of curvilinear coordinates, suitable to be reduced to orthogonal form. As an illustration of the potentiality of the
Gabbasov, R.   +3 more
core   +1 more source

Apnea-hypopnea index, nocturnal arousals, oxygen desaturation and structural brain changes: A population-based study

open access: yesNeurobiology of Sleep and Circadian Rhythms, 2016
Sleep apnea has been related to brain changes such as atrophy. However, which component of sleep apnea, the apnea-hypopnea index (AHI), nocturnal oxygen desaturation or arousals, can explain this association is unclear.
Lisette A. Zuurbier   +7 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report [PDF]

open access: yes, 2017
This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages ...
Adelberger, Eric   +250 more
core   +2 more sources

White Matter

open access: yes
Citation: 'white matter' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11380 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

TractSeg - Fast and accurate white matter tract segmentation [PDF]

open access: yesNeuroImage, 2018
Jakob Wasserthal   +2 more
semanticscholar   +1 more source

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

open access: yesActa Neuropathologica Communications, 2016
Vascular cognitive impairment is the second most common form of dementia. The pathogenic pathways leading to vascular cognitive impairment remain unclear but clinical and experimental data have shown that chronic reactive astrogliosis occurs within white
Raman Saggu   +6 more
semanticscholar   +1 more source

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