Results 121 to 130 of about 197,800 (388)

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

Journal of Psychiatry & Neuroscience, 2019
Background We investigated the association between white matter hyperintensity location and depressive symptoms in a memoryclinic population using lesion–symptom mapping.
A. Leeuwis, Nick A. Weaver, J. M. Biesbroek, L. Exalto, H. Kuijf, A. Hooghiemstra, N. Prins, P. Scheltens, F. Barkhof, W. M. van der Flier, G. Biessels   +10 more
semanticscholar   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

Subclinical Cerebrovascular Disease Increases the Risk of Incident Stroke and Mortality: The Northern Manhattan Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe effects of white matter hyperintensity volume and subclinical brain infarcts on the risk of incident stroke, its ischemic subtypes, and mortality require further study in diverse samples.
Clinton B. Wright, Chuanhui Dong, Enmanuel J. Perez, Janet De Rosa, Mitsuhiro Yoshita, Tatjana Rundek, Charles DeCarli, Jose Gutierrez, Mitchell S. V. Elkind, Ralph L. Sacco   +9 more
doaj   +1 more source

White matter hyperintensity shape in relation to long‐term small vessel disease progression in community‐dwelling older adults [PDF]

, 2023
Jasmin Annica Keller, Sigurður Sigurdsson, Mark A. van Buchem, Lenore J. Launer, Matthias J.P. van Osch, Vilmundur Guðnason, Jeroen H.J.M. de Bresser   +6 more
openalex   +1 more source

Structural and Functional Imaging of Motor Outcomes in Twins With Perinatal Stroke: A Case Report

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Perinatal arterial ischemic stroke (AIS) affects 1 in 4000 live births. Dystonia, affecting ~20% of children following AIS, is characterized by involuntary muscle contractions and abnormal movements. Why some develop dystonia post AIS, while others do not, remains unclear.
Prisca Hsu, Trish Domi, Cecilia Jobst, Min Sheng, Amanda Robertson, Erum Syed, Pradeep Krishnan, Douglas Cheyne, Nomazulu Dlamini   +8 more
wiley   +1 more source

Sudden unexpected death in an infant with L-2-hydroxyglutaric aciduria [PDF]

, 2018
Inherited metabolic disorders are the cause of a small but significant number of sudden unexpected deaths in infancy. We report a girl who suddenly died at 11months of age, during an intercurrent illness.
Ballhausen, Diana, Bonafé, Luisa, Boulat, Olivier, Jakobs, Cornelis, Jequier Gygax, Marine, Meagher-Villemure, Kathleen, Roulet-Perez, Eliane, Salomons, Gajja, Superti-Furga, Andrea   +8 more
core  

Baseline cognitive dispersion is related to increases in white matter hyperintensities in cognitively preserved older individuals [PDF]

, 2023
Lídia Mulet‐Pons, Lídia Vaqué‐Alcázar, Cristina Solé‐Padullés, María Cabello‐Toscano, Kilian Abellaneda‐Pérez, Ruben Perellón‐Alfonso, Oriol Perera‐Cruz, Núria Bargalló, David Bartrés‐Faz   +8 more
openalex   +1 more source

Isolated Corticospinal Tract Lesions as an Early Manifestation of Adrenoleukodystrophy in Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Purpose X‐linked adrenoleukodystrophy (ALD) encompasses a wide range of neurological manifestations, classically described as distinct phenotypes including childhood cerebral adrenoleukodystrophy and adult‐onset adrenomyeloneuropathy (AMN).
Elle Winter, Amanda Nagy, Yedda Li, Otto Rapalino, Catherine L. Becker, Joseph Locascio, Camilo Jaimes, Florian Eichler   +7 more
wiley   +1 more source

Multi-stage semi-supervised learning enhances white matter hyperintensity segmentation

Frontiers in Computational Neuroscience
IntroductionWhite matter hyperintensities (WMHs) are frequently observed on magnetic resonance (MR) images in older adults, commonly appearing as areas of high signal intensity on fluid-attenuated inversion recovery (FLAIR) MR scans. Elevated WMH volumes
Kauê T. N. Duarte, Kauê T. N. Duarte, Abhijot S. Sidhu, Abhijot S. Sidhu, Murilo C. Barros, David G. Gobbi, David G. Gobbi, Cheryl R. McCreary, Cheryl R. McCreary, Feryal Saad, Richard Camicioli, Richard Camicioli, Eric E. Smith, Mariana P. Bento, Richard Frayne, Richard Frayne, Richard Frayne, Richard Frayne   +17 more
doaj   +1 more source

Reward circuitry is perturbed in the absence of the serotonin transporter [PDF]

, 2009
The serotonin transporter (SERT) modulates the entire serotonergic system in the brain and influences both the dopaminergic and norepinephrinergic systems.
Bearer, Elaine L., Boulat, Benoit, Jacobs, Russell E., Janvelyan, Davit, Zhang, Xiaowei   +4 more
core   +1 more source