Results 211 to 220 of about 197,800 (388)

Cerebral blood flow regulation, central arterial stiffness and traumatic brain injury: Effects of aerobic exercise training

Experimental Physiology, EarlyView.
Abstract Advanced age is the strongest risk factor for Alzheimer's disease and related dementias (ADRDs). Traumatic brain injury (TBI) has also been recognized as a risk factor for ADRD, potentially contributing to an earlier onset of the disease. Thus, elucidating the mechanisms underlying brain ageing and TBI is critical for developing strategies to ...
Tsubasa Tomoto, Kan Ding, C. Munro Cullum, Rong Zhang   +3 more
wiley   +1 more source

Early Detection of Neuroinflammation and White Matter Damage Following Dorsal Spinal Nerve Root Sectioning in a Nonhuman Primate Model

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2786-2796, May 2026.
ABSTRACT Purpose Dorsal rhizotomy, or spinal dorsal nerve root lesioning, is a surgical procedure used to treat intractable nerve pain by selectively severing sensory afferent nerve roots. This study aimed to evaluate whether multiparametric MRI, including diffusion tensor imaging (DTI), quantitative magnetization transfer (qMT), chemical exchange ...
Feng Wang, John C. Gore, Li Min Chen
wiley   +1 more source

The correlation between medial pattern of intracranial arterial calcification and white matter hyperintensities [PDF]

, 2023
Heng Du, Jianrong Zheng, Xuelong Li, Yanjing Dong, Yajing Cheng, Cong Liu, Jun Hu, Xiangyan Chen   +7 more
openalex   +1 more source

Infantile‐Onset Ascending Hereditary Spastic Paraplegia due to a Homozygous ALS2 Exons 24–25 Deletion: Expanding the Genotypic Spectrum

American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 929-936, April 2026.
ABSTRACT We describe a novel homozygous intragenic deletion in the ALS2 gene in an 8‐year‐old boy with Infantile‐onset Ascending Hereditary Spastic Paraplegia (IAHSP) and oculomotor apraxia, thereby contributing to the expanding genetic landscape of ALS2‐related disorders.
Vito Luigi Colona, Maria Gnazzo, Silvia Genovese, Gessica Vasco, Lorena Travaglini, Maurizio Sabbadini, Marina Macchiaiolo, Francesco Nicita, Jacopo Sartorelli, Carmelo Piscopo, Enrico Castelli, Enrico Bertini, Andrea Bartuli, Antonio Novelli, Gessica Della Bella, Davide Vecchio   +15 more
wiley   +1 more source

Longitudinal Behavior Phenotype Hallmarks in RNU4‐2 Syndrome: Implications for Clinical Management

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 3, Page 205-211, April 2026.
ABSTRACT Pathogenic variants in the non‐coding spliceosomal gene RNU4‐2 underlie ReNU syndrome, one of the most prevalent monogenic causes of neurodevelopmental disorders, accounting for ~0.4% of cases. Despite increasing recognition, little is known about the longitudinal behavioral and neuropsychiatric phenotype of affected individuals. We report two
Paola Francesca Ajmone, Claudia Rigamonti, Francesca Brasca, Donatella Milani, Chiara Ranci Ortigosa, Maria Iascone, Lucrezia Goisis, Annalaura Torella, Maria Antonella Costantino   +8 more
wiley   +1 more source

ASL 4D MRA Intracranial Vessel Segmentation With Deep Learning U‐Nets

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 2384-2396, April 2026.
ABSTRACT Purpose To propose a spatio‐temporal U‐Net based network (4DST) that exploits both spatial and dynamic information while avoiding memory‐intensive 4D convolutional layers for ASL‐based non‐contrast enhanced 4‐dimensional MR angiography (4D MRA) vessel segmentation.
Sang Hun Chung, Zihan Wang, Tianrui Zhao, Zhitao Li, Chase S. Krumpelman, Sarah J. Moum, Sameer A. Ansari, Lirong Yan   +7 more
wiley   +1 more source

Evaluating the relationship between right-to-left shunt and white matter hyperintensities in migraine patients: A systematic review and meta-analysis [PDF]

, 2022
Joshua Y. P. Yeo, Claire Goh, Ying Kiat Tan, Bryan T. S. Sim, Beverly L. X. Chan, Nicholas Syn, Yinghao Lim, Amanda Chan, Vijay K. Sharma, Jonathan Ong, Leonard L.L. Yeo, Ching‐Hui Sia, Benjamin Yong‐Qiang Tan   +12 more
openalex   +1 more source

Mitochondrial DNA Depletion Syndrome 1 (MTDPS1)—A Novel Cause of Premature Ovarian Insufficiency

Clinical Genetics, Volume 109, Issue 4, Page 784-787, April 2026.
We describe a woman with MNGIE due to a novel homozygous TYMP nonsense variant and propose MNGIE as the cause of her premature ovarian insufficiency—a rarely reported association—highlighting the need to consider mitochondrial disease in unexplained POI, especially in atypical, consanguineous presentations. ABSTRACT Mitochondrial DNA depletion syndrome
Michael Matheou, Helen Turner, Deborah Shears, Fredrik Karpe   +3 more
wiley   +1 more source

When Weak Becomes Strong: Robust Quantification of White Matter Hyperintensities in Brain MRI scans [PDF]

, 2020
Oliver Werner, Kimberlin M. H. van Wijnen, Wiro J. Niessen, Marius de Groot, Meike W. Vernooij, Florian Dubost, Marleen de Bruijne   +6 more
openalex   +1 more source

An Autopsy Case With Fragile X‐Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya, Kazuhiro Ishii, Taiki Sato, Masayuki Noguchi, Akira Tamaoka, Yuko Saito   +5 more
wiley   +1 more source