Results 241 to 250 of about 197,800 (388)

Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer's disease biomarkers

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION The locus coeruleus (LC), the first region to contain tau pathology in Alzheimer's disease (AD), releases norepinephrine, which has a neuroprotective role. We examined whether LC integrity relates to whole‐brain integrity and how AD biomarkers may moderate this relationship.
Emilie Foyard, Tao Blanchard, Brigitte Landeau, Léa Chauveau, Mikaël Naveau, Géraldine Poisnel, Eric Bui, Gaël Chetelat, Robin de Flores, for the Medit‐Ageing Research Group   +9 more
wiley   +1 more source

The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Emerging evidence highlights the central role of peripheral immune–metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critical immune–metabolic hub linking systemic homeostasis to central neurodegeneration.
Jingsi Yan, Jiayu Zhang, Xinyi Ye, Huihong Wang, Hang Li, Weirong Li, Huifei Wu, Wei Zhao   +7 more
wiley   +1 more source

Resistance training and subcortical vascular cognitive impairment: A 12‐month randomized trial

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). METHODS We conducted a 12‐month randomized trial comparing PRT versus balance and tone exercises (BAT) on the ...
Teresa Liu‐Ambrose, Ryan S. Falck, Elizabeth Dao, Rachel A. Crockett, Cindy K. Barha, Narlon C. Boa Sorte Silva, Walid A. Alkeridy, John R. Best, Ging‐Yuek R. Hsiung, Thalia S. Field, Kenneth M. Madden, Jennifer C. Davis, Lisanne F. ten Brinke, Roger C. Tam   +13 more
wiley   +1 more source

Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Cortical cerebral microinfarcts (CMIs) are associated with cognitive dysfunction and dementia, while their evolution on sequential magnetic resonance imaging (MRI) remains unclear. METHODS The study enrolled 490 patients (72.5 ± 7.9 years) from a memory‐clinic cohort, with 5‐year follow‐up.
Jiannan Huang, Christopher Chen, Wei Ying Tan, Jiangbo Cui, Eddie Jun Yi Chong, Narayanaswamy Venketasubramanian, Saima Hilal   +6 more
wiley   +1 more source

Endogenous Repair in Vanishing White Matter

Annals of Neurology, Volume 99, Issue 3, Page 737-747, March 2026.
[Color figure can be viewed at www.annalsofneurology.org] Objective Vanishing white matter is a leukodystrophy with remarkable regional variation in disease severity. The cerebral and cerebellar white matter chronically degenerates, while stress‐induced episodes of rapid neurological deterioration coincide with the appearance of acute focal lesions in ...
Bonnie C. Plug, Jodie H.K. Man, Marjolein Breur, Erik Nutma, Menno D. Stellingwerff, Truus E.M. Abbink, Marianna Bugiani, Marjo S. van der Knaap   +7 more
wiley   +1 more source

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

Annals of Neurology, Volume 99, Issue 3, Page 668-683, March 2026.
[Color figure can be viewed at www.annalsofneurology.org] Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains ...
Yue Qiao, Adrien Ter Schiphorst, Yi Xu, Jean‐Claude Baron, Wenbo Zhao   +4 more
wiley   +1 more source

White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype

, 2020
Anne‐Katrin Giese, Markus D. Schirmer, Adrian V. Dalca, Ramesh Sridharan, Kathleen Donahue, Marco Nardin, Robert E. Irie, Elissa C. McIntosh, Steven J. T. Mocking, Huichun Xu, John W. Cole, Eva Giralt‐Steinhauer, Jordi Jiménez-Conde, Christina Jern, Dawn Kleindorfer, Robin Lemmens, Johan Wassélius, Arne Lindgren, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Słowik, Vincent Thijs, Bradford B. Worrall, Daniel Woo, Steven J. Kittner, Patrick F. McArdle, Braxton D. Mitchell, Jonathan Rosand, James F. Meschia, Ona Wu, Polina Golland, Natalia S. Rost, Anne‐Katrin Giese, Markus D. Schirmer, Adrian V. Dalca, Ramesh Sridharan, Kathleen Donahue, Marco Nardin, Robert E. Irie, Elissa C McIntos, Steven J. T. Mocking, Huichun Xu, John W. Cole, Eva Giralt‐Steinhauer, Jordi Jiménez-Conde, Christina Jern, Dawn Kleindorfer, Robin Lemmens, Johan Wassélius, Arne Lindgren, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Słowik, Vincent Thijs, Bradford B. Worrall, Daniel Woo, Patrick F. McArdle, Braxton D. Mitchell, Jonathan Rosand   +62 more
openalex   +2 more sources

Early Microstructural Changes in the Left Inferior Fronto‐Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed

Brain and Behavior, Volume 16, Issue 3, March 2026.
Using fixel‐based analysis in Alzheimer's disease, we found that reduced fiber density value of the left inferior fronto‐occipital fasciculus is associated with both slower gait speed and impairments in executive and visuospatial functions, suggesting this white matter tract as a shared neural substrate for cognitive‐motor decline.
Shan‐Wen Liu, Lin‐Lin Yao, Fang‐Bo Li, Xiao‐Ting Ma, Xiao‐Fen Weng, Meng Li, Jiangtao Zhu, Chun‐Feng Liu, Chun‐Yuan Zhang, Hua Hu   +9 more
wiley   +1 more source

Carotid intraplaque neovascularization increases the risk of white matter hyperintensity progression: a prospective cohort study. [PDF]

Front Neurosci
Zhang H, He J, Xu J, Wang R, Yan Y, Feng Y, Cao S, Xia M.   +7 more
europepmc   +1 more source