Results 101 to 110 of about 143,855 (296)

Encephalitis with reversible splenial and deep cerebral white matter lesions associated with Epstein–Barr virus infection in adults [PDF]

, 2017
Yanjun Guo,1 Shuhui Wang,1 Bin Jiang,1 Jianle Li,1 Lei Liu,2 Jiawei Wang,2 Weiqin Zhao,1 Jianping Jia1 1Department of Neurology, Beijing Friendship Hospital, Capital Medical University. Beijing, China; 2Department of Neurology, Beijing Tongren Hospital,
Wang SH, Liu L, Jiang B, Li JL, Guo YJ, Zhao WQ, Wang J, Jia J   +7 more
core  

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies

Frontiers in Neurology, 2019
Background: White matter hyperintensities of presumed vascular origin (WMH) are a common finding in elderly people and a growing social malady in the aging western societies. As a manifestation of cerebral small vessel disease, WMH are considered to be a
Benedikt M. Frey, Marvin Petersen, Carola Mayer, Maximilian Schulz, Bastian Cheng, Götz Thomalla   +5 more
doaj   +1 more source

FMRI guided DTI at the grey-white matter interface : with application to a connectivity analysis of the default mode network in Urbach-Wiethe disease [PDF]

, 2011
Includes abstract.Includes bibliographical references.The cerebral cortex is composed of a thin layer of Grey Matter (GM), functionally subdivided into discrete regions which are connected in a large scale network via White Matter (WM) tracts. With fMRI (
Baasch, Roland
core  

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Identifying mechanisms underlying the pathogenesis of age-associated periventricular white matter lesions [PDF]

, 2020
Age-associated white matter lesions (WML) appear as hyperintense signals on T2- weighted magnetic resonance imaging (MRI) scans and are associated with dementia and cognitive decline.
Fadul, Motaz
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Ethnoracial disparities in gray matter atrophy are mediated by structural disconnectivity in multiple sclerosis

Annals of Clinical and Translational Neurology
Objective To investigate ethnoracial disparities in gray matter (GM) atrophy, the contribution of white matter lesions and consequent structural disconnectivity among patients with multiple sclerosis (MS).
Ahmed Bayoumi, Joseph A. Thomas, Breanna R. Alonzo, Juan Jimenez, Christopher M. Orlando, Carlos A. Pérez, Khader M. Hasan, Jerry S. Wolinsky, John A. Lincoln   +8 more
doaj   +1 more source

White Matter Lesion Progression [PDF]

, 2015
Background and Purpose—White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from ...
Hofer, Edith, Cavalieri, Margherita, Bis, Joshua C., Decarli, Charles, Fornage, Myriam, Sigurdsson, Sigurdur, Srikanth, Velandai, Trompet, Stella, Verhaaren, Benjamin F.J., Wolf, Chris, Yang, Qiong, Adams, Hieab H.H., Amouyel, Philippe, Beiser, Alex, Buckley, Brendan M., Callisaya, Michele, Chauhan, Ganesh, de Craen, Anton J.M., Dufouil, Carole, van Duijn, Cornelia M., Ford, Ian, Freudenberger, Paul, Gottesman, Rebecca F., Gudnason, Vilmundur, Heiss, Gerardo, Hofman, Albert, Lumley, Thomas, Martinez, Oliver, Mazoyer, Bernard, Moran, Chris, Niessen, Wiro J., Phan, Thanh, Psaty, Bruce M., Satizabal, Claudia L., Sattar, Naveed, Schilling, Sabrina, Shibata, Dean K., Slagboom, P. Eline, Smith, Albert, Stott, David J., Taylor, Kent D., Thomson, Russell, Töglhofer, Anna M., Tzourio, Christophe, van Buchem, Mark, Wang, Jing, Westendorp, Rudi G.J., Gwen Windham, B., Vernooij, Meike W., Zijdenbos, Alex, Beare, Richard, Debette, Stéphanie, Ikram, M. Arfan, Jukema, J. Wouter, Launer, Lenore J., Longstreth, W. T., Mosley, Thomas H., Seshadri, Sudha, Schmidt, Helena, Schmidt, Reinhold   +59 more
openaire   +2 more sources