Results 81 to 90 of about 143,855 (296)

Major risk factors for the appearance of white-matter lesions on MRI in hypertensive patients with controlled blood pressure [PDF]

, 2012
Takeshi Takami1, Shigeru Yamano2, Sadanori Okada3, Mio Sakuma4, Takeshi Morimoto4, Hiroshi Hashimoto5, Satoshi Somekawa3, Yoshihiko Saito31Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2Department of Internal Medicine, Nara ...
Morimoto T, Sakuma M, Somekawa S, Saito Y, Takami T, Okada S, Yamano S, Hashimoto H   +7 more
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SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Understanding progression in primary progressive multiple sclerosis: a longitudinal clinical and magnetic resonance imaging study [PDF]

, 2010
The work in this thesis applies magnetization transfer imaging (MTI) and conventional MRI measures (brain volume, T2 lesion load and enhancing lesions) to investigate the mechanisms underlying progression in primary progressive multiple sclerosis ...
Khaleeli, Z.
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Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain [PDF]

, 2014
Cerebral white matters lesions (WML) are seen in 94% of the population aged 64 and over and are associated with cognitive decline and depression. We used immunohistochemistry and stereological methods on post mortem brain samples derived from the ...
Highley, J.R., Shaw, P.J., Wharton, S.B., Gebril, O.H., Kirby, J., O'Brien, J.T., Barber, R., Simpson, J.E., Brayne, C., Lewis, C.E., Kalaria, R.N., Ince, P.G.   +11 more
core   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

A novel PSMB8 isoform associated with multiple sclerosis lesions induces P-body formation

Frontiers in Cellular Neuroscience
IntroductionMultiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Current therapies primarily target the inflammatory component of the disease and are highly effective in early stages of MS while ...
Benjamin C. Shaw, Jessica L. Williams, Jessica L. Williams   +2 more
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Dual Inversion Recovery Magnetic Resonance Imaging's Diagnostic Value for Estimating the Overall Load of Multiple Sclerosis Lesions and its Anatomical Distribution

مجله كليه طب الكندي
B Background: In young adults, multiple sclerosis is a prevalent chronic inflammatory demyelinating condition. It is characterized by white matter affection, but many individuals also have significant gray matter involvement.
Mahmoud Mishaal Mohamed, Maryam Issa Al-Ani, Gheyath Al Gawwam, Murtadha Hussein Alrubaye, Ahmed Al-Imam Al-Imam   +4 more
doaj   +1 more source

HAM/TSP: association between white matter lesions on magnetic resonance imaging, clinical and cerebrospinal fluid findings

Arquivos de Neuro-Psiquiatria, 2012
OBJECTIVE: To investigate the association between clinical data, white matter lesions and inflammatory cerebrospinal fluid (CSF) findings in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHOD: We studied brain and cervical spinal
Marzia Puccioni-Sohler, Emerson Gasparetto, Mauro Jorge Cabral-Castro, Carla Slatter, Cecilia M. Vidal, Romeu Domingues Cortes, Bruce R. Rosen, Caterina Mainero   +7 more
doaj   +1 more source

Cerebral white matter lesions and depressive symptoms in elderly adults [PDF]

, 2000
BACKGROUND: There is evidence for a vascular cause of late-life depression. Cerebral white matter lesions are thought to represent vascular abnormalities.
Hofman, A. (Albert), de Groot, JC (Jan Cees), Groot, J.C. (Jan Cees) de, Leeuw, H.F. (Frank) de, Leeuw, FE, Jolles, J. (Jellemer), Breteler, M.M.B. (Monique), Jolles, J, Hofman, Bert, Breteler, Monique, Oudkerk, M, Oudkerk, M. (Matthijs)   +11 more
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