Results 111 to 120 of about 5,103,599 (293)

The extracellular matrix in multiple sclerosis: an update

Brazilian Journal of Medical and Biological Research, 2001
Extracellular matrix (ECM) molecules play important roles in the pathobiology of the major human central nervous system (CNS) inflammatory/demyelinating disease multiple sclerosis (MS). This mini-review highlights some recent work on CNS endothelial cell
R.A. Sobel
doaj   +1 more source

Neuropathology of white matter lesions in vascular cognitive impairment.

, 2002
The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes.
Englund, Elisabet
core   +2 more sources

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source

Mathematical modeling for the prediction of cerebral white matter lesions based on clinical examination data.

PLoS ONE, 2019
Cerebral white matter lesions are ischemic symptoms caused mainly by microangiopathy; they are diagnosed by MRI because they show up as abnormalities in MRI images.
Yuya Shinkawa, Takashi Yoshida, Yohei Onaka, Makoto Ichinose, Kazuo Ishii   +4 more
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Major risk factors for the appearance of white-matter lesions on MRI in hypertensive patients with controlled blood pressure

, 2012
Takeshi Takami1, Shigeru Yamano2, Sadanori Okada3, Mio Sakuma4, Takeshi Morimoto4, Hiroshi Hashimoto5, Satoshi Somekawa3, Yoshihiko Saito31Department of Internal Medicine, Clinic Jingumae, Kashihara, Japan; 2Department of Internal Medicine, Nara ...
Morimoto T, Sakuma M, Somekawa S, Saito Y, Takami T, Okada S, Yamano S, Hashimoto H   +7 more
core  

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

White Matter Lesions and Migrain

Türk Nöroloji Dergisi, 2007
OBJECTIVE: There are close correlations between subclinical ischaemic strokes and white matter lesions (WML) in migraineurs as shown by imaging studies. T2-weighted images of migraine patients displayed hyperintense lesions in 6-29% of the cases in different studies.
Fahrettin Över, Şebnem Bıçakcı, Yakup Sarıca, Yaşar Sertdemir   +3 more
openaire   +1 more source

Periventricular cerebral white matter lesions predict rate of cognitive decline

, 2002
The prospect of declining cognitive functions is a major fear for many elderly persons. Cerebral white matter lesions, as commonly found with magnetic resonance imaging, have been associated with cognitive dysfunction in cross-sectional studies.
Jolles, J., Leeuw, FE, Breteler, MMB, Breteler, M.M., Hofman, A., van Gijn, J, de Leeuw, F E., Hofman, Bert, Breteler, Monique, de Leeuw, FE, de Groot, JC; id_orcid, Groot, J.C.de, de Groot, JC (Jan Cees), de Groot, JC, Hofman, A, Oudkerk, M., Jolles, J, Oudkerk, M, Oudkerk, M; id_orcid   +18 more
core   +1 more source