Results 121 to 130 of about 13,623,762 (302)

White matter matters: a multimodal approach to investigate white matter microstructure and metabolism

, 2014
White matter connects different brain areas and applies electrical insulation to the neuron’s axons with myelin sheaths in order to enable quick signal transmission.
Giezendanner, Stéphanie
core  

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Sex differences for normalised grey matter volume and normalised white matter volume in control and MCI subjects.

, 2013
(A) No significant differences in white matter volume were found between males and females for control or MCI conditions.
Máiréad Bartley (317137), Desmond O’Neill (317135), David Prvulovic (290948), Franck Lamberton (299445), Laurence O’Dwyer (290940), Arun L. W. Bokde (206207), Harald Hampel (183230), Colby Tanner (299447), Michael Ewers (317132), Tara Coughlan (317141), Yetunde O. Faluyi (317133), Bernard Mazoyer (317134), Rónán Collins (317139)   +12 more
core   +1 more source

Cognitive state following stroke: the predominant role of preexisting white matter lesions.

PLoS ONE, 2014
Background and purposeStroke is a major cause of cognitive impairment and dementia in adults, however the role of the ischemic lesions themselves, on top of other risk factors known in the elderly, remains controversial.
Efrat Kliper, Einor Ben Assayag, Ricardo Tarrasch, Moran Artzi, Amos D Korczyn, Shani Shenhar-Tsarfaty, Orna Aizenstein, Hen Hallevi, Anat Mike, Ludmila Shopin, Natan M Bornstein, Dafna Ben Bashat   +11 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Detailed results of the comparative analysis of white matter volume.

, 2013
Areas where white matter volume is significantly decreased in each patient group compared to controls and in PSP compared to bvFTD ...
Marie Vidailhet (227046), Bruno Dubois (174565), Richard Levy (174577), Julien Lagarde (180888), Jean-Christophe Corvol (73149), Fanny Pineau (487366), Isabelle Le Ber (487367), Romain Valabrègue (5591558)   +7 more
core   +1 more source

Polygenic Index for Sleep Duration and Brain Changes over Time

Medical Sciences
Background: Sleep is a complex physiological process, crucial for cognitive functioning, emotional regulation, and overall health. Recent advances in genomics and neuroimaging have illuminated the intricate relationship between genetics, sleep ...
Tsapanou Angeliki, Chapman Silvia, Lee Seonjoo, Habeck Christian, Gu Yian, Stern Yaakov   +5 more
doaj   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source