Results 121 to 130 of about 260,120 (295)

Sedentary Time and White Matter Hyperintensity Volume in Older Adults

Medicine & Science in Sports & Exercise, 2019
ABSTRACTPurposeCerebrovascular disease in the form of white matter hyperintensities (WMH) increases with age and is associated separately with sedentary time and reduced kidney function. A better understanding of the relationships among these variables would help clarify whether sedentary time should be considered more closely in older adults at ...
Ulf G, Bronas, Alana, Steffen, Catherine, Dion, Elizabeth A, Boots, Konstantinos, Arfanakis, David X, Marquez, Melissa, Lamar   +6 more
openaire   +3 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Cognitive state following stroke: the predominant role of preexisting white matter lesions.

PLoS ONE, 2014
Background and purposeStroke is a major cause of cognitive impairment and dementia in adults, however the role of the ischemic lesions themselves, on top of other risk factors known in the elderly, remains controversial.
Efrat Kliper, Einor Ben Assayag, Ricardo Tarrasch, Moran Artzi, Amos D Korczyn, Shani Shenhar-Tsarfaty, Orna Aizenstein, Hen Hallevi, Anat Mike, Ludmila Shopin, Natan M Bornstein, Dafna Ben Bashat   +11 more
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Polygenic Index for Sleep Duration and Brain Changes over Time

Medical Sciences
Background: Sleep is a complex physiological process, crucial for cognitive functioning, emotional regulation, and overall health. Recent advances in genomics and neuroimaging have illuminated the intricate relationship between genetics, sleep ...
Tsapanou Angeliki, Chapman Silvia, Lee Seonjoo, Habeck Christian, Gu Yian, Stern Yaakov   +5 more
doaj   +1 more source

Megalencephalic leucoencephalopathy with cysts: defect in chloride currents and cell volume regulation

, 2011
Megalencephalic leucoencephalopathy with subcortical cysts is a genetic brain disorder with onset in early childhood. Affected infants develop macrocephaly within the first year of life, after several years followed by slowly progressive, incapacitating ...
van der Knaap, M.S., Boor, Ilja, Scheper, G.C., Estévez, R., Johannes C. Lodder, Mansvelder, H.D., Arjen B. Brussaard, Ilja Boor, van der Knaap, Marjo S., Brussaard, A.B., Postma, N.L., Raúl Estévez, Postma, Nienke L., Marjo S. van der Knaap, Estévez, Raul, Brussaard, Arjen B., Scheper, Gert C., Capdevila-Nortes, Xavier, Lodder, J.C., Nienke L. Postma, Xavier Capdevila-Nortes, Duarri, A., Duarri, Anna, Mansvelder, H.D.; id_orcid, Lodder, Johannes C., Ridder, Margreet C., Gert C. Scheper, Boor, I., Anna Duarri, Huibert D. Mansvelder, Mansvelder, Huibert D., Margreet C. Ridder, Ridder, M.C., Capdevila-Nortes, X.   +33 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

The impact of different aetiologies on the cognitive performance of frontal patients.

, 2015
Neuropsychological group study methodology is considered one of the primary methods to further understanding of the organisation of frontal 'executive' functions.
Bozzali, M, Lecce, Francesca, Cipolotti, L, Lecce, F, Healy, C, Shallice, Tim, Bolsover, F, Bozzali, Marco, White, Mark, Healy, Colm, Bolsover, Fay, Spanò, B, CIPOLOTTI, Lisa, Bozzali, M., Shallice, T, Chan, Edgar, Chan, E, White, M, Spanò, Barbara   +18 more
core   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source