Results 111 to 120 of about 260,120 (295)

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Regional white matter volume correlated with discounting severity.

, 2013
White matter volume in the parahippocampus/hippocampus (A) and right prefrontal subgyral area (B) correlated with delay discounting rates after whole brain correction.
Rongjun Yu (277015)
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1

NeuroImage: Clinical, 2016
Background: Myotonic dystrophy type 1 (DM1) represents a multisystemic disorder in which diffuse brain white and gray matter alterations related to clinical and genetic features have been described.
Stefano Zanigni, Stefania Evangelisti, Maria Pia Giannoccaro, Federico Oppi, Roberto Poda, Antonio Giorgio, Claudia Testa, David Neil Manners, Patrizia Avoni, Laura Ludovica Gramegna, Nicola De Stefano, Raffaele Lodi, Caterina Tonon, Rocco Liguori   +13 more
doaj   +1 more source

Replication Study of Chr17q25 With Cerebral White Matter Lesion Volume

, 2011
Background and Purpose— Recently, the first genomewide association study on cerebral white matter lesion burden identified chr17q25 to be significantly associated with white matter lesions.
Krestin, Gabriel, Vernooij, Meike; id_orcid, Verhaaren, Ben, Albert Hofman, van der Lugt, Aad, Hofman, Bert, Breteler, Monique, Gabriel P. Krestin, Ikram, Arfan, Wiro J. Niessen, André G. Uitterlinden, M. Arfan Ikram, Aad van der Lugt, Benjamin F.J. Verhaaren, Niessen, Wiro, Fernando Rivadeneira, Boer, Renske, Uitterlinden, André; id_orcid, Monique M.B. Breteler, Meike W. Vernooij, Renske de Boer, Rivadeneira, Fernando   +21 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Body Composition Is Not Related to Structural or Vascular Brain Changes

Frontiers in Neurology, 2019
Background: It is known that obesity [measured with body mass index (BMI)] relates to brain structure and markers of cerebral small vessel disease (CSVD). However, BMI may not adequately represent body composition.
Pauline H. Croll, Pauline H. Croll, Daniel Bos, Daniel Bos, Mohammad Arfan Ikram, Fernando Rivadeneira, Fernando Rivadeneira, Trudy Voortman, Meike W. Vernooij, Meike W. Vernooij   +9 more
doaj   +1 more source

White matter hyperintensities and within-person variability in community-dwelling adults aged 60–64 years

, 2007
Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60–64 years.
Wen, W, Dear, K, Anstey, KJ, Christensen, H, Bunce, D, Sachdev, P   +5 more
core  

Regional information of changed gray and white matter volume.

, 2013
Regional information of changed gray and white matter volume.
Qiyong Gong (178081), Ji Chen (69329), Jiaxing Zhang (363434), Ming Fan (102594), Haiyan Zhang (176919)   +4 more
core   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source