Results 101 to 110 of about 260,120 (295)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Association between altered white matter networks and post operative ventricle volume in shunt-treated pediatric hydrocephalus

Brain Research Bulletin
Objective: The objective of this study was to use probabilistic tractography in combination with white matter microstructure metrics to characterize differences in white matter networks between shunt-treated pediatric hydrocephalus patients relative to ...
Renee-Marie Ragguett, Roy Eagleson, Sandrine de Ribaupierre   +2 more
doaj   +1 more source

Tract-defined regional white matter hyperintensities and memory

NeuroImage: Clinical, 2020
White matter hyperintensities (WMH) are common radiological findings among older adults and strong predictors of age-related cognitive decline. Recent work has implicated WMH in the pathogenesis and symptom presentation of Alzheimer's disease (AD), which
Batool Rizvi, Patrick J. Lao, Juliet Colón, Christiane Hale, Kay C. Igwe, Atul Narkhede, Mariana Budge, Jennifer J. Manly, Nicole Schupf, Adam M. Brickman   +9 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

npj Science of Food
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies ...
Shutaro Shibata, Moeko Noguchi-Shinohara, Ayano Shima, Taro Ozaki, Yuta Usui, Yasuyuki Taki, Kazuhiro Uchida, Takanori Honda, Jun Hata, Tomoyuki Ohara, Tatsuya Mikami, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Kenjiro Ono, On behalf of the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group   +18 more
doaj   +1 more source

Blood Pressure Control in Aging Predicts Cerebral Atrophy Related to Small-Vessel White Matter Lesions

Frontiers in Aging Neuroscience, 2017
Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia.
Kyle C. Kern, Clinton B. Wright, Kaitlin L. Bergfield, Kaitlin L. Bergfield, Megan C. Fitzhugh, Kewei Chen, Kewei Chen, Kewei Chen, James R. Moeller, Nooshin Nabizadeh, Mitchell S. V. Elkind, Ralph L. Sacco, Yaakov Stern, Yaakov Stern, Charles S. DeCarli, Gene E. Alexander, Gene E. Alexander, Gene E. Alexander, Gene E. Alexander   +18 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Abnormal anatomical connectivity between the amygdala and orbitofrontal cortex in conduct disorder [PDF]

, 2012
Objective: previous research suggested that structural and functional abnormalities within the amygdala and orbitofrontal cortex contribute to the pathophysiology of Conduct Disorder (CD).
Cindy C Hagan, Luca Passamonti (121912), Ian M Goodyer, Fairchild, G, Ian Nimmo-Smith (121918), Calder, AJ, Cindy C. Hagan, Ian Nimmo-Smith, Andrew J. Calder, Ian M. Goodyer, Goodyer, Ian M., Cindy C. Hagan (121920), Nimmo-Smith, I, Andrew J Calder, Alex Fornito (121916), Alex Fornito, Hagan, Cindy C., Passamonti, L, Hagan, Cindy, Calder, Andrew, Luca Passamonti, Andrew J. Calder (121921), Graeme Fairchild, Goodyer, IM, Nimmo-Smith, Ian, Goodyer, Ian, Passamonti, Luca, Fornito, Alex, Hagan, CC, Fornito, Alexander, Calder, Andrew J., Fornito, A, Graeme Fairchild (121914), Ian M. Goodyer (118260), Fairchild, Graeme   +34 more
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source