Results 31 to 40 of about 260,120 (295)

White matter hyperintensity volume in pre-diabetes, diabetes and normoglycemia [PDF]

BMJ Open Diabetes Research & Care, 2021
Introduction As white matter hyperintensities (WMHs) of the brain are associated with an increased risk of stroke, cognitive decline, and depression, elucidating the associated risk factors is important. In addition to age and hypertension, pre-diabetes and diabetes may play important roles in the development of ...
Sergio Grosu, Roberto Lorbeer, Felix Hartmann, Susanne Rospleszcz, Fabian Bamberg, Christopher L Schlett, Franziska Galie, Sonja Selder, Sigrid Auweter, Margit Heier, Wolfgang Rathmann, Katharina Mueller-Peltzer, Karl-Heinz Ladwig, Annette Peters, Birgit B Ertl-Wagner, Sophia Stoecklein   +15 more
openaire   +6 more sources

The spectrum of Ischemia-induced white matter injury varies with age [PDF]

, 2013
Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Zammit, Christian, Muscat, Richard, Valentino, Mario   +2 more
core   +1 more source

Depression in small-vessel disease relates to white matter ultrastructural damage, not disability. [PDF]

, 2014
OBJECTIVE: To determine whether cerebral small-vessel disease (SVD) is a specific risk factor for depression, whether any association is mediated via white matter damage, and to study the role of depressive symptoms and disability on quality of life (QoL)
Morris, RG, Brookes, RL, Lawrence, AJ, Morris, Robin G., Lawrence, Andrew J.; id_orcid, Herbert, Vanessa, Herbert, V, Brookes, Rebecca L., Markus, Hugh S., Markus, HS   +9 more
core   +1 more source

Depressive symptoms and neuroanatomical structures in community-dwelling women: A combined voxel-based morphometry and diffusion tensor imaging study with tract-based spatial statistics

NeuroImage: Clinical, 2014
Depressive symptoms, even at a subclinical level, have been associated with structural brain abnormalities. However, previous studies have used regions of interest or small sample sizes, limiting the ability to generalize the results.
Yayoi K. Hayakawa, Hiroki Sasaki, Hidemasa Takao, Naoto Hayashi, Akira Kunimatsu, Kuni Ohtomo, Shigeki Aoki   +6 more
doaj   +1 more source

Increase of blood-brain barrier leakage is related to cognitive decline in vascular mild cognitive impairment

BMC Neurology, 2021
Background Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild cognitive impairment (vMCI), has only been validated by a few studies.
Man Li, Yue Li, Long Zuo, Wenli Hu, Tao Jiang   +4 more
doaj   +1 more source

White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines. [PDF]

, 2012
The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and ...
Lamberton, F., Hampel, Harald, Miller, Julia, Rujescu, D., Laurence O'Dwyer, Lamberton, Franck, Prvulovic, David, Matura, S., Scheibe, M., O'Dwyer, L.G., David Prvulovic, O'Dwyer, Laurence, Hampel, H., Franck Lamberton, Dan Rujescu, Harald Hampel, Scheibe, Monika, Julia Miller, Prvulovic, D., Silke Matura, Monika Scheibe, Matura, Silke, Miller, J., Rujescu, Dan   +23 more
core   +1 more source

APOE ɛ 2 is associated with white matter hyperintensity volume in CADASIL [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2015
Apolipoprotein E ( APOE) increases the risk for Alzheimer’s disease ( ɛ4 allele) and cerebral amyloid angiopathy ( ɛ2 and ɛ4), but its role in small vessel disease (SVD) is debated. Here we studied the effects of APOE on white matter hyperintensity volume (WMHV) in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Gesierich, Benno, Opherk, Christian, Rosand, Jonathan, Gonik, Mariya, Malik, Rainer, Jouvent, Eric, Hervé, Dominique, Adib Samii, Poneh, Bevan, Steve, Pianese, Luigi, Silvestri, Serena, DOTTI, MARIA, DE STEFANO, NICOLA, van der Grond, Jeroen, Boon, Elles Mj, Pescini, Francesca, Rost, Natalia, Pantoni, Leonardo, Lesnik Oberstein, Saskia A, FEDERICO, ANTONIO, Ragno, Michele, Markus, Hugh S, Tournier Lasserve, Elisabeth, Chabriat, Hugues, Dichgans, Martin, Duering, Marco, Ewers, Michael   +26 more
openaire   +7 more sources

Brain White Matter Structure and Amyloid Deposition in Black and White Older Adults: The ARIC‐PET Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background White matter abnormalities are a common feature of aging and Alzheimer disease, and tend to be more severe among Black individuals. However, the extent to which white matter abnormalities relate to amyloid deposition, a marker of Alzheimer ...
Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman   +9 more
doaj   +1 more source

White matter volume differences per timepoint comparison.

, 2023
White matter volume differences per timepoint comparison.
Roelien H. Enting (15290851), Anouk van der Hoorn (587531), Jesse D. de Groot (15401476), Bart R. J. van Dijken (12152218), Hiska L. van der Weide (15401479)   +4 more
core   +1 more source

White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms [PDF]

Molecular Psychiatry, 2013
Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those ...
Paillère Martinot, M-L, Lemaitre, H, Artiges, E, Miranda, R, Goodman, R, Penttilä, J, Struve, M, Fadai, T, Kappel, V, Poustka, L, Conrod, P, Banaschewski, T, Barbot, A, Barker, G J, Büchel, C, Flor, H, Gallinat, J, Garavan, H, Heinz, A, Ittermann, B, Lawrence, C, Loth, E, Mann, K, Paus, T, Pausova, Z, Rietschel, M, Robbins, T W, Smolka, M N, Schumann, G, Martinot, J-L   +29 more
openaire   +5 more sources