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PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
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Ultrastructure analysis of white spot syndrome virus (WSSV)

Archives of Virology, 2019
In this study, two aspects of the ultrastructure of white spot syndrome virus (WSSV) were identified: (i) The virus nucleocapsids were disassembled, and transmission electron microscopy (TEM) image analysis confirmed that the nucleocapsids were composed of stacked ring segments rather than the usual helix system, with each ring segment consisting of ...
Li Li, Yongcong Hong, Da Huo, Pumo Cai
openaire   +2 more sources

Latest advances in white spot syndromes: New findings and interpretations

Progress in Retinal and Eye Research, 2023
White spot syndromes (WSS) pose challenges in the field of ophthalmology, particularly in terms of accurate diagnosis and effective management. However, recent advancements in multimodal imaging (MMI) have significantly contributed to our understanding of WSS, allowing for improved characterization of these inflammatory chorioretinopathies.
Cicinelli, Maria Vittoria, Ramtohul, Prithvi, Marchese, Alessandro, Bandello, Francesco, Bailey Freund, K, Miserocchi, Elisabetta, Jampol, Lee M   +6 more
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Genetic variation among isolates of White spot syndrome virus

Archives of Virology, 2004
White spot syndrome virus (WSSV), member of a new virus family called Nimaviridae, is a major scourge in worldwide shrimp cultivation. Geographical isolates of WSSV identified so far are very similar in morphology and proteome, and show little difference in restriction fragment length polymorphism (RFLP) pattern.
Marks, H., Goldbach, R.W., Vlak, J.M., van Hulten, M.C.W.   +3 more
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White spot syndrome virus (WSSV) interaction with crayfish haemocytes

Fish & Shellfish Immunology, 2006
WSSV particles were detected in separated granular cells (GCs) and semigranular cells (SGCs) by in situ hybridisation from WSSV-infected crayfish and the prevalence of WSSV-infected GCs was 5%, whereas it was 22% in SGCs. This indicates that SGCs are more susceptible to WSSV and that this virus replicated more rapidly in SGCs than in GCs and as a ...
Pikul, Jiravanichpaisal, Siripavee, Sricharoen, Irene, Söderhäll, Kenneth, Söderhäll   +3 more
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Cellular responses in crustaceans under white spot syndrome virus infection

Fish & Shellfish Immunology, 2023
Innate immunity plays the most important system responsible for protecting crustaceans against invading pathogens. White spot syndrome virus (WSSV) is considered a serious pathogen in crustaceans with high cumulative mortality and morbidity in infected animals.
Ngoc Tuan Tran, Huifen Liang, Jinkun Li, Taoqiu Deng, Md Akibul Hasan Bakky, Ming Zhang, Shengkang Li   +6 more
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Shrimp SIRT4 promotes white spot syndrome virus replication

Fish & Shellfish Immunology
In WSSV pathogenesis, the molecular mechanisms and the key host factors that regulate the viral replication and morphogenesis remain unclear. However, like most viruses, WSSV is known to induce metabolic reprogramming in several metabolic pathways including the host glutamine metabolism, and several recent reports have suggested that the sirtuins SIRT3,
Yu Kent Tan, Brandon Rafael de Jesús Castillo-Corea, Ramya Kumar, Ping-Hung Lai, Shih-Shun Lin, Han-Ching Wang   +5 more
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Silencing shrimp white spot syndrome virus (WSSV) genes by siRNA

Antiviral Research, 2007
White spot syndrome virus (WSSV) is a major shrimp pathogen causing large economic losses all over the world. So far, however, there is no efficient approach to control this virus. RNA interference (RNAi), which has been applied to silence virus genes in eukaryotic organisms.
Xu, Jianyang, Han, Fang, Zhang, Xiaobo
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Thioredoxin of Litopenaeus vannamei facilitated white spot syndrome virus infection

Journal of Invertebrate Pathology, 2015
Thioredoxin (TRX), a major intracellular antioxidant, has a wide range of biological functions. It was up-regulated and targeted by WSSV. However, the relevance of TRX with WSSV infection and signaling pathway remains largely unknown. Sequence analysis indicated that TRX might interact with the WSSV030 (VP362) and WSSV454 (thymidine kinase-thymidylate ...
Peng-fei, Liu, Qing-hui, Liu, Yin, Wu, Jie, Huang   +3 more
openaire   +2 more sources