Results 91 to 100 of about 53,883 (296)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Elevated hemoglobin glycation index identify non-diabetic individuals at increased risk of kidney dysfunction [PDF]

, 2017
Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has ...
Andreozzi, F, Fiorentino, Tv, Marini, Ma, Perticone, F, Sciacqua, A, Sesti, G, Succurro, E   +6 more
core   +2 more sources

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Sensitivitas Berbagai Stadia Kepiting Bakau (Scylla paramamosain Estampador) terhadap White Spot Syndrome Virus [PDF]

, 2005
Mud crab is the most commercial crabs which are highly sold because of their delicious taste and high protein content. In nature, the capture intensity of this crab is very high so the population would decrease rapidly.
MAHARANI, RIA IKA, SURANTO,, ZAFRAN,
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Mud crab susceptibility to disease from white spot syndrome virus is species-dependent

BMC Research Notes, 2010
Background Based on a report for one species (Scylla serrata), it is widely believed that mud crabs are relatively resistant to disease caused by white spot syndrome virus (WSSV).
Sritunyalucksana Kallaya, Krittanai Chartchai, Udompetcharaporn Attasit, Mangkalanan Seksan, Somboonna Naraporn, Flegel TW   +5 more
doaj   +1 more source

Effect of dietary pigment on growth performance and disease resistance in black tiger shrimp post larva (Penaeus monodon, Fabricius) [PDF]

, 2005
Effects of dietary pigment on survival and disease (white spot syndrome virus: WSSV) resistance in black tiger shrimp post larva (Penaeus monodon, Fabricius) (PL15) for a 30-day period were studied.
Boonyaratpalin, M., Kiriratnikom, S., Kliangpradit, A., Supamattaya, K., Tanmark, N.   +4 more
core  

Verified and potential pathogens of predatory mites (Acari: Phytoseiidae) [PDF]

, 2008
Several species of phytoseiid mites (Acari: Phytoseiidae), including species of the genera Amblyseius, Galendromus, Metaseiulus, Neoseiulus, Phytoseiulus and Typhlodromus, are currently reared for biological control of various crop pests and/or as model ...
A Janssen, A Jeyaprakash, AR Weeks, AR Weeks, AR Weeks, AR Weeks, B Lighthart, C Schütte, C Schütte, C Schütte, C Schütte, C Schütte, C Schütte, C Schütte, C Schütte, D Skirvin, D Skirvin, DA Raworth, DC Margolies, DG Boucias, DL Johanowicz, DL Johanowicz, DL Johanowicz, DL Johanowicz, DR Horton, DS Yao, E Zchori-Fein, E Zchori-Fein, EAM Beerling, EAM Beerling, EAM Beerling, ES Arutunyan, G Poinar, G Šut’áková, G Šut’áková, G Šut’áková, G Šut’áková, G Šut’áková, G Šut’áková, GJ Moraes De, H Evans, IP Furtado, JA McMurtry, JAJ Breeuwer, JC Lenteren van, JC Lenteren van, JJ Becnel, LA Corpuz-Raros, LE Olsen, LK Tanigoshi, LK Tanigoshi, LPS Geest van der, M Dicke, M Dicke, M Dicke, M Enigl, M Enigl, M Vrie van de, MA Hoy, ME Courcy Williams De, ME Huigens, MS Hunter, MW Sabelis, MW Sabelis, MY Steiner, MY Steiner, MY Steiner, P Schausberger, PP Sikorowski, R Gols, R Pukall, R Stouthamer, R Stouthamer, R Zemek, RT Hess, S Bjørnson, S Bjørnson, S Bjørnson, S Bjørnson, S Bjørnson, S Bjørnson, S Bjørnson, S Bjørnson, S Blümel, S Keller, T Maeda, T Maeda, TG Andreadis, TVM Groot, Y Tanada   +89 more
core   +2 more sources