Results 91 to 100 of about 2,879,199 (294)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Gene-interleaving patterns of synteny in the Saccharomyces cerevisiae genome: are they proof of an ancient genome duplication event?

Biology Direct, 2007
Background Recent comparative genomic studies claim local syntenic gene-interleaving relationships in Ashbya gossypii and Kluyveromyces waltii are compelling evidence for an ancient whole-genome duplication event in Saccharomyces cerevisiae. We here test,
Sun Feng-Jie, LeDuc Richard, Ruedi Elizabeth A, Martin Nicolas, Caetano-Anollés Gustavo   +4 more
doaj   +1 more source

Studying Whole-Genome Duplication Using Experimental Evolution of Chlamydomonas

, 2023
In this chapter, we present the use of Chlamydomonas reinhardtii in experiments designed to study the evolutionary impacts of whole genome duplication. We shortly introduce the algal species and depict why it is an excellent model for experimental evolution.
Bafort, Quinten, Prost, Lucas, Aydogdu, Eylem, Van de Vloet, Antoine, Casteleyn, Griet, Van de Peer, Yves, De Clerck, Olivier   +6 more
openaire   +3 more sources

Supplemental data for: "Effect of whole-genome duplication on the evolutionary rescue of sterile hybrid monkeyflowers"

, 2020
Hybridisation is a creative evolutionary force, increasing genomic diversity, and facilitating adaptation and even speciation. Hybrids often face significant challenges to become established, including reduced fertility arising from genomic ...
De Storme, Nico, Meeus, Sofie, Geelen, Danny, Šemberová, Kristýna, Vallejo-Marin, Mario   +4 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Comparative Inference of Duplicated Genes Produced by Polyploidization in Soybean Genome

International Journal of Genomics, 2013
Soybean (Glycine max) is one of the most important crop plants for providing protein and oil. It is important to investigate soybean genome for its economic and scientific value. Polyploidy is a widespread and recursive phenomenon during plant evolution,
Yanmei Yang, Jinpeng Wang, Jianyong Di
doaj   +1 more source

The Grayling Genome Reveals Selection on Gene Expression Regulation after Whole-Genome Duplication [PDF]

, 2018
Whole-genome duplication (WGD) has been a major evolutionary driver of increased genomic complexity in vertebrates. One such event occurred in the salmonid family ∼80 Ma (Ss4R) giving rise to a plethora of structural and regulatory duplicate-driven ...
Leif Asbjørn Vøllestad, Sissel Jentoft, Varadharajan, Srinidhi, Kjetill S Jakobsen, Sandve, Simen R., Mulugeta, Teshome D., Teshome D Mulugeta, Jakobsen, Kjetill Sigurd, Mulugeta, Teshome Dagne, Hvidsten, Torgeir R.,, Sandve, Simen Rød, Simen R Sandve, Gillard, Gareth B., Hvidsten, Torgeir R., Torgeir R Hvidsten, Gillard, Gareth Benjamin, Srinidhi Varadharajan, Ole K Tørresen, Tørresen, Ole K., Gareth B Gillard, Vøllestad, Leif Asbjørn, Jentoft, Sissel, Nederbragt, Alexander J., Alexander J Nederbragt, Jakobsen, Kjetill S., Nederbragt, Alexander Johan, Lien, Sigbjørn, Hvidsten, Torgeir Rhoden, Sigbjørn Lien   +28 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea [PDF]

, 2014
Background: Brassica oleracea is a valuable vegetable species that has contributed to human health and nutrition for hundreds of years and comprises multiple distinct cultivar groups with diverse morphological and phytochemical attributes.
John Nixon, Denoeud, France, Parkin, Isobel AP, Annaliese S Mason, Town, Chris D, Huebert, Terry, Sharpe, Andrew G., Manoli, Sahana, Bancroft, Ian, France Denoeud, Sateesh Kagale, Just, J\ue9r\ue9my, Robinson, Stephen J., Vivek Krishnakumar, Clarke, Carling, Links, Matthew G., Robinson, Stephen J, Wayne E Clarke, Guy Barker, Barker, Guy C., Shelby L Bidwell, Koh, Chushin, Moore, Jonathan D., Sharpe, Andrew G, Jacqueline Batley, Edwards, David, Clarke, Wayne E., Harry Belcram, Jérémy Just, Bidwell, Shelby L., Just, Jérémy, Carling Clarke, Jonathan Moore, Edwards, Dave, Nelson, Matthew N, David Edwards, Batley, Jacqueline, Matthew N Nelson, Stephen J Robinson, Sahana Manoli, Bidwell, Shelby L, Pires, J. Chris, Parkin, Isobel A. P., Chalhoub, Boulos, Terry Huebert, Andrew H Paterson, Krishnakumar, Vivek, Belcram, Harry, H., Walley, Peter G, Bender, Tricia, Tricia Bender, Town, Chris D., Nelson, Matthew N., King, Graham, J Pires, Mason, Annaliese S., Graham King, Pires, Chris J., Matthew G Links, Nixon, John, Chris D Town, Boulos Chalhoub, Links, Matthew G, Ian Bancroft, Belcram, Harry, Walley, Peter G., Mason, Annaliese S, Paterson, Andrew H, Walley, Peter Glen, Paterson, Andrew H., Moore, Jonathan, Barker, Guy, Kagale, Sateesh, Wang, Xiyin, Tang, Haibao, Pires, J Chris, Isobel AP Parkin, Pires, J., Andrew G Sharpe, Clarke, Wayne E, Xiyin Wang, Haibao Tang, Peter G Walley, Chushin Koh   +83 more
core   +1 more source