Results 91 to 100 of about 3,779,882 (303)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis : a retrospective observational study [PDF]

, 2013
This study was funded by Wellcome Trust (grant number 098051), European Union (FP7 grant number 241 476), Medical Research Council, Global Alliance for TB Drug Development, and European and Developing Country Clinical Trials Partnership (grants IP.2007 ...
van Helden, Paul, Bryant, J.M., Bentley, S.D., Louw, Cheryl, Bateson, Anna L C, Boeree, M.J., Chuchottaworn, Charoen, Mahayiddin, Aziah A, Hoelscher, Michael, Gillespie, Stephen Henry, Mwaigwisya, Solomon, Parkhill, J., Bentley, Stephen D, Pym, Alex, Ahmad Mahayiddin, Aziah, Boeree, Martin J, Diacon, Andreas, Harris, Simon R, Harris, S.R., McHugh, Timothy D, Bryant, Josephine M, Chuchottaworn, C, Wright, Laura, Parkhill, Julian, Hunt, Robert D, Dawson, Rodney, Sanne, Ian M, Gillespie, Stephen H, Diacon, Andreas H   +28 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Construction and evaluation of a whole genome microarray of Chlamydomonas reinhardtii [PDF]

, 2011
Toepel J, Albaum S, Arvidsson S, et al. Construction and evaluation of a whole genome microarray of Chlamydomonas reinhardtii. BMC Genomics. 2011;12(1): 579.ABSTRACT: BACKGROUND: Chlamydomonas reinhardtii is widely accepted as a model organism regarding ...
La Russa, Marco, Goesmann, Alexander ; https://orcid.org/, Arvidsson, S., Toepel, Jörg, Goesmann, A., Samuel Arvidsson, La Russa, M., Marco la Russa, Kristin Rogge, Toepel Jörg, Albaum, S. P., Rogge Kristin, Alexander Goesmann, Albaum, Stefan ; https://orcid.org/, Kruse, Olaf ; https://orcid.org/, Olaf Kruse, Jörg Toepel, Arvidsson Samuel, Rogge, K., Goesmann Alexander, Albaum Stefan P, Toepel, J., Stefan P Albaum, Kruse Olaf, la Russa Marco, Albaum, S., Rogge, Kristin, Kruse, O.   +27 more
core   +2 more sources

Deterministic whole-genome amplification of single cells

, 2022
S.69-86This chapter describes a single-cell whole genome amplification method (WGA) that has been originally published under the name "Single Cell Comparative Genomic Hybridization (SCOMP)" (Klein et al., Proc Natl Acad Sci U S A 96(8):4494-4499, 1999 ...
Czyz, Zbigniew Tadeusz, Klein, Christoph A.   +1 more
core   +1 more source

Leveraging the Assembly of the Durum Wheat Genome cv. Svevo

, 2017
Tetraploid wheat species, with his two wild and cultivated subspecies T. turgidum ssp. dicoccoides and ssp. durum, is a cornerstone of the wheat polyploidy complex.
The International Durum Wheat Sequencing Consortium, The International Durum wheat Genome Sequencing Consortium, L. Cattivelli, M. Maccaferri   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

An improved genome of the model marine alga Ostreococcus tauri unfolds by assessing Illumina de novo assemblies [PDF]

, 2014
Background: Cost effective next generation sequencing technologies now enable the production of genomic datasets for many novel planktonic eukaryotes, representing an understudied reservoir of genetic diversity. O.
Moreau, Hervé, Van De Peer, Yves, Adam Eyre-Walker, Château, Annie, Van de Peer, Y., Stephane Rombauts, Carré, Isabelle, Eyre-Walker, Adam, Rivals, E., Peer, Yves van de, Wendy Schackwitz, Schackwitz, Wendy, Benoit Piégu, Moreau, H., Schackwitz, W., Grimsley, Nigel, Evelyne Derelle, Rombauts, Stephane, Eyre Walker, Adam, Blanc-Mathieu, R., Eyre-Walker, A., Verhelst, B., Blanc-Mathieu, Romain, Bouget, François-Yves, Hervé Moreau, Nigel Grimsley, Rivals, Eric, Piégu, Benoit, Isabelle Carré, François-Yves Bouget, Derelle, Evelyne, Eric Rivals, Carré, I., Gwenaël Piganeau, Derelle, E., Bram Verhelst, Verhelst, Bram, Annie Château, Romain Blanc-Mathieu, Bouget, F.-Y., Château, A., Carré, Isabelle A., Piégu, B., Grimsley, N., Piganeau, G., Rombauts, S., Piganeau, Gwenaël, Blanc Mathieu, Romain, Yves Van de Peer   +48 more
core   +1 more source