Results 101 to 110 of about 916,807 (296)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. [PDF]

, 2014
Initial results from sequencing studies suggest that there are relatively few low-frequency (<5%) variants associated with large effects on common phenotypes. We performed low-pass whole-genome sequencing in 680 individuals from the InCHIANTI study to
Almeida, Marcio, Bandinelli, Stefania, Blangero, John, Curran, Joanne E, Duggirala, Ravindranath, Ferrucci, Luigi, Frayling, Timothy M, Gaulton, Kyle, Gibbs, J Raphael, Göring, Harald HH, Hernandez, Dena, Johnson, Matthew P, Jun, Goo, Li, Qibin, Lin, Haoxiang, Mccarthy, Mark I, Melzer, David, Murray, Anna, Nalls, Mike, Pearson, Richard, Perry, John RB, Rivas, Manny, Shen, Juan, Singleton, Andrew, Tanaka, Toshiko, Tuke, Marcus A, Weedon, Michael N, Wood, Andrew R, Xu, Christopher S   +28 more
core   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Chills and Thrills of Whole Genome Sequencing

CoRR, 2013
A slightly different version of this article appears in IEEE Computer Magazine, Vol. 48, No. 2, February 2015, under the title "Whole Genome Sequencing: Revolutionary Medicine or Privacy Nightmare"
Erman Ayday, Emiliano De Cristofaro, Jean-Pierre Hubaux, Gene Tsudik   +3 more
openaire   +2 more sources

Whole Genome Amplification and Reduced-Representation Genome Sequencing of Schistosoma japonicum Miracidia.

PLoS Neglected Tropical Diseases, 2017
BackgroundIn areas where schistosomiasis control programs have been implemented, morbidity and prevalence have been greatly reduced. However, to sustain these reductions and move towards interruption of transmission, new tools for disease surveillance ...
Jonathan A Shortt, Daren C Card, Drew R Schield, Yang Liu, Bo Zhong, Todd A Castoe, Elizabeth J Carlton, David D Pollock   +7 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Data on whole genome sequencing of extrapulmonary tuberculosis clinical isolates from India

Data in Brief, 2018
This article describes the whole genome sequencing data from 5 extrapulmonary tuberculosis clinical isolates. The whole genome sequencing was carried out on Illumina MiSeq platform to identify single nucleotide variations (SNVs) associated with drug ...
Jayshree Advani, Kusum Sharma, Renu Verma, Oishi Chatterjee, Hitendra S. Solanki, Aman Sharma, Subhash Varma, Manish Modi, Pallab Ray, Megha Sharma, M.S. Dhillion, Akhilesh Pandey, Harsha Gowda, T.S. Keshava Prasad   +13 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Whole‐genome sequencing and the physician [PDF]

Clinical Genetics, 2012
Thorogood, A., Knoppers, B. M., Dondorp, W. J., de Wert, G. M. W. R.   +3 more
openaire   +3 more sources