Results 51 to 60 of about 552,282 (159)
TelomereHunter – in silico estimation of telomere content and composition from cancer genomes
BMC Bioinformatics, 2019 Background Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrations ...
Lars Feuerbach +16 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2017 BackgroundIn areas where schistosomiasis control programs have been implemented, morbidity and prevalence have been greatly reduced. However, to sustain these reductions and move towards interruption of transmission, new tools for disease surveillance ...
Jonathan A Shortt +7 more
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Whole‐genome sequencing and the physician [PDF]
Clinical Genetics, 2012 Thorogood, A. +3 more
openaire +3 more sources
Data on whole genome sequencing of extrapulmonary tuberculosis clinical isolates from India
Data in Brief, 2018 This article describes the whole genome sequencing data from 5 extrapulmonary tuberculosis clinical isolates. The whole genome sequencing was carried out on Illumina MiSeq platform to identify single nucleotide variations (SNVs) associated with drug ...
Jayshree Advani +13 more
doaj +1 more source
FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA
Nature CommunicationsAnalysis of DNA methylation in cell-free DNA reveals clinically relevant biomarkers but requires specialized protocols such as whole-genome bisulfite sequencing.
Yaping Liu +16 more
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Identifying insertion mutations by whole-genome sequencing
BioTechniques, 2011 Insertion mutagenesis via mobile genetic element is a common technique for the analysis of gene function in model organisms. Next-generation sequencing offers an attractive approach for localizing the site of insertion, but alignment-based mapping of ...
Harold E. Smith
doaj +1 more source
Mapping Challenging Mutations by Whole-Genome Sequencing
G3: Genes, Genomes, Genetics, 2016 Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists
Harold E. Smith +3 more
doaj +1 more source
Optimal sequencing depth design for whole genome re-sequencing in pigs
BMC Bioinformatics, 2019 Background As whole-genome sequencing is becoming a routine technique, it is important to identify a cost-effective depth of sequencing for such studies.
Yifan Jiang +4 more
doaj +1 more source
Whole genome sequencing in Mycobacterium tuberculosis
Annals of Translational Medicine, 2019 Fighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) requires a proper and personalized use of new antitubercular drugs. To achieve this goal, the sensitivity profile to antitubercular drug should be available in a short-time and results should be highly reliable be used for patient-care.
Andrea, Spitaleri +3 more
openaire +2 more sources
BMC Medical Genomics, 2018 Background To address the need for more effective genomics training, beginning in 2012 the Icahn School of Medicine at Mount Sinai has offered a unique laboratory-style graduate genomics course, “Practical Analysis of Your Personal Genome” (PAPG), in ...
Michael D. Linderman +9 more
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