Results 81 to 90 of about 912,763 (246)

Identifying insertion mutations by whole-genome sequencing

BioTechniques, 2011
Insertion mutagenesis via mobile genetic element is a common technique for the analysis of gene function in model organisms. Next-generation sequencing offers an attractive approach for localizing the site of insertion, but alignment-based mapping of ...
Harold E. Smith
doaj   +1 more source

Validating Whole Genome Nanopore Sequencing, using Usutu Virus as an Example [PDF]

, 2020
Bas B. Oude Munnink, David F. Nieuwenhuijse, Reina S. Sikkema, Marion Koopmans   +3 more
openalex   +1 more source

Whole genome sequencing in paediatric channelopathy and cardiomyopathy

Frontiers in Cardiovascular Medicine
BackgroundPrecision medicine in paediatric cardiac channelopathy and cardiomyopathy has a rapid advancement over the past years. Compared to conventional gene panel and exome-based testing, whole genome sequencing (WGS) offers additional coverage at the ...
Sit Yee Kwok, Anna Ka Yee Kwong, Julia Zhuo Shi, Connie Fong Ying Shih, Mianne Lee, Christopher C. Y. Mak, Martin Chui, Sabrina Tsao, Brian Hon Yin Chung   +8 more
doaj   +1 more source

Mapping Challenging Mutations by Whole-Genome Sequencing

G3: Genes, Genomes, Genetics, 2016
Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists
Harold E. Smith, Amy S. Fabritius, Aimee Jaramillo-Lambert, Andy Golden   +3 more
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Sensitive Long-Indel-Aware Alignment of Sequencing Reads

, 2013
The tremdendous advances in high-throughput sequencing technologies have made population-scale sequencing as performed in the 1000 Genomes project and the Genome of the Netherlands project possible.
Marschall, Tobias, Schönhuth, Alexander
core  

The Sugarcane genome sequencing effort: An overview of the strategy, goals and existing data : [Abstract W538] [PDF]

, 2010
Sugarcane is a major feedstock used for biofuel production worldwide. Sugarcane cultivars (Saccharum spp) are derived from interspecific hybridization obtained a century ago by crossing Saccharum officinarum (2n=8x=80) and S.
D'Hont, Angélique, Henry, Robert, Ming, Ray, Paterson, Andrew H., Potier, Fabien, Souza, Glaucia   +5 more
core  

Optimal sequencing depth design for whole genome re-sequencing in pigs

BMC Bioinformatics, 2019
Background As whole-genome sequencing is becoming a routine technique, it is important to identify a cost-effective depth of sequencing for such studies.
Yifan Jiang, Yao Jiang, Sheng Wang, Qin Zhang, Xiangdong Ding   +4 more
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Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature [PDF]

, 2018
Katharina Schwarze, James Buchanan, Jenny C. Taylor, Sarah Wordsworth   +3 more
openalex   +1 more source

Impacts of incorporating personal genome sequencing into graduate genomics education: a longitudinal study over three course years

BMC Medical Genomics, 2018
Background To address the need for more effective genomics training, beginning in 2012 the Icahn School of Medicine at Mount Sinai has offered a unique laboratory-style graduate genomics course, “Practical Analysis of Your Personal Genome” (PAPG), in ...
Michael D. Linderman, Saskia C. Sanderson, Ali Bashir, George A. Diaz, Andrew Kasarskis, Randi Zinberg, Milind Mahajan, Sabrina A. Suckiel, Micol Zweig, Eric E. Schadt   +9 more
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Enriched whole genome sequencing identified compensatory mutations in the RNA polymerase gene of rifampicin-resistant Mycobacterium leprae strains

Infection and Drug Resistance, 2018
Mallika Lavania,1 Itu Singh,1 Ravindra P Turankar,1 Anuj Kumar Gupta,2 Madhvi Ahuja,1 Vinay Pathak,1 Utpal Sengupta1 1Stanley Browne Laboratory, The Leprosy Mission Trust India, TLM Community Hospital Nand Nagari, 2Agilent Technologies India Pvt Ltd ...
Lavania M, Singh I, Turankar RP, Gupta AK, Ahuja M, Pathak V, Sengupta U   +6 more
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