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Whole brain radiotherapy for brain metastases
BMJ, 2016Optimising its use and application in the context of new treatments A recent large non-inferiority trial reported that whole brain radiotherapy did not improve survival or quality of life in adults with brain metastases from non-small cell lung cancer, when compared with corticosteroids and supportive care.1 QUARTZ (Quality of Life after Treatment ...
Orit, Kaidar-Person +2 more
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Whole-Brain Radiotherapy in the Management of Brain Metastasis
Journal of Clinical Oncology, 2006Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000 Americans annually. The prognosis for these patients is poor, with median survival times measured in months. In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of ...
Deepak, Khuntia +3 more
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International Journal of Radiation Oncology*Biology*Physics, 2008
To compare the outcome of surgical resection followed by whole brain radiotherapy (WBRT) with WBRT alone in patients treated for single brain metastasis.The data from 195 patients with single brain metastases were retrospectively evaluated. Of the 195 patients, 99 underwent resection of the metastasis followed by WBRT and 96 underwent WBRT alone. Seven
Dirk, Rades +5 more
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To compare the outcome of surgical resection followed by whole brain radiotherapy (WBRT) with WBRT alone in patients treated for single brain metastasis.The data from 195 patients with single brain metastases were retrospectively evaluated. Of the 195 patients, 99 underwent resection of the metastasis followed by WBRT and 96 underwent WBRT alone. Seven
Dirk, Rades +5 more
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Hippocampus sparing in whole-brain radiotherapy
Strahlentherapie und Onkologie, 2014Radiation treatment techniques for whole-brain radiation therapy (WBRT) have not changed significantly since development of the procedure. However, the recent development of novel techniques such as intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT) and helical tomotherapy, as well as an increasing body of evidence ...
F, Oskan +5 more
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The Use of Palliative Whole Brain Radiotherapy in the Management of Brain Metastases
Clinical Oncology, 2012To describe the use of palliative whole brain radiotherapy (WBRT) in the management of brain metastases in the general cancer population and to identify factors associated with variations in its use.We conducted a retrospective population-based study of patients who died of cancer in Ontario from 1984 to 2007 and identified those who received WBRT ...
W J Mackillop, W Kong, W J Mackillop
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Brain metastases: fractionated whole-brain radiotherapy
2018Brain metastases are the most common malignant adult intracranial tumors, occurring in approximately 10-30% of cancer patients, and generally lead to a poor prognosis. The incidence has been steadily rising, likely due to longer survival from newer systemic therapies and increased utilization of magnetic resonance imaging.
Tony J C, Wang, Paul D, Brown
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Role of Whole-Brain Radiotherapy
2020Whole-brain radiotherapy (WBRT) has been integral to the management of brain metastases for several decades. Early studies demonstrated the efficacy of WBRT in relieving neurologic symptoms related to intracranial disease and improving survival for patients with brain metastases.
Connor Lynch +2 more
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Whole brain radiotherapy for the treatment of multiple brain metastases
2006Brain radiotherapy is used to treat cancer patients who have brain metastases resulting from various primary malignancies.To assess the effectiveness and adverse effects of whole brain radiotherapy (WBRT) in adult patients with multiple metastases to the brain.CENTRAL (The Cochrane Library), MEDLINE, EMBASE, CANCERLIT, and CINAHL were searched ...
M N, Tsao +5 more
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Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases.
Journal of Clinical Oncology, 1998PURPOSE Evaluation of the treatment outcome after radiosurgery (RS) alone or in combination with whole-brain radiotherapy (WBRT) with special attention to prescribed dose and its influence on local control and survival. PATIENTS AND METHODS Between September 1984 and January 1997, 236 patients with 311 brain metastases treated with radiosurgery met the
Pirzkall A +6 more
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