Results 61 to 70 of about 3,996,555 (297)

Whole brain radiotherapy (WBRT) after local treatment of brain metastases in melanoma patients: Statistical Analysis Plan

Trials, 2019
Background The WBRTMel trial is a multinational, open-label, phase III randomised controlled trial comparing whole brain radiotherapy (WBRT) to observation following local treatment of one to three melanoma brain metastases with surgery and/or ...
Serigne N. Lo, Angela M. Hong, Lauren E. Haydu, Tasnia Ahmed, Elizabeth J. Paton, Victoria Steel, George Hruby, Anh Tran, Rachael L. Morton, Anna K. Nowak, Janette L. Vardy, Katharine J. Drummond, Haryana M. Dhillon, Catherine Mandel, Richard A. Scolyer, Mark R. Middleton, Bryan H. Burmeister, John F. Thompson, Gerald B. Fogarty   +18 more
doaj   +1 more source

Short report: Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: A pilot study.

PLoS ONE, 2023
BackgroundRadiotherapy has an important role in the treatment of brain metastases but carries risk of short and/or long-term toxicity, termed radiation-induced brain injury (RBI).
Chen Makranz, Asael Lubotzky, Hai Zemmour, Ruth Shemer, Benjamin Glaser, Jonathan Cohen, Myriam Maoz, Eli Sapir, Marc Wygoda, Tamar Peretz, Noam Weizman, Jon Feldman, Ross A Abrams, Alexander Lossos, Yuval Dor, Aviad Zick   +15 more
doaj   +1 more source

Combination of vorinostat with whole-brain radiotherapy in the treatment of brain metastases.

Journal of Clinical Oncology, 2010
TPS181 Background: A third of patients with solid malignancies develop brain metastases. Expected overall survival is 4-7 months depending on age, performance status, and extracranial disease.
Y. Lawrence, R. Pfeffer, Maria Werner-Wasik, H. Choy, Adam Dicker   +4 more
openaire   +2 more sources

Recent Update on Neurosurgical Management of Brain Metastasis [PDF]

, 2022
Brain metastasis (BM), classified as a secondary brain tumor, is the most common malignant central nervous system tumor whose median overall survival is approximately 6 months.
박현호, 장종희, 강석구, 유지환   +3 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Single-Isocenter Volumetric Modulated Arc Therapy vs. CyberKnife M6 for the Stereotactic Radiosurgery of Multiple Brain Metastases

Frontiers in Oncology, 2020
Introduction: Stereotactic radiosurgery (SRS) is becoming more frequently used for patients with multiple brain metastases (BMs). Single-isocenter volumetric modulated arc therapy (SI-VMAT) is an emerging alternative to dedicated systems such as ...
Rami A. El Shafie, Rami A. El Shafie, Eric Tonndorf-Martini, Eric Tonndorf-Martini, Daniela Schmitt, Daniela Schmitt, Aylin Celik, Aylin Celik, Dorothea Weber, Kristin Lang, Kristin Lang, Laila König, Laila König, Simon Höne, Simon Höne, Tobias Forster, Tobias Forster, Bastian von Nettelbladt, Bastian von Nettelbladt, Sebastian Adeberg, Sebastian Adeberg, Jürgen Debus, Jürgen Debus, Jürgen Debus, Jürgen Debus, Stefan Rieken, Stefan Rieken, Stefan Rieken, Denise Bernhardt, Denise Bernhardt   +29 more
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

A Bayesian network meta-analysis of whole brain radiotherapy and stereotactic radiotherapy for brain metastasis

Medicine, 2017
This study was conducted to compare the effects of whole brain radiotherapy (WBRT) and stereotactic radiotherapy (SRS) in treatment of brain metastasis.A systematical retrieval in PubMed and Embase databases was performed for relative literatures on the effects of WBRT and SRS in treatment of brain metastasis.
Yuan, Xi, Liu, Wen-Jie, Li, Bing, Shen, Ze-Tian, Shen, Jun-shu, Zhu, Xi-Xu   +5 more
openaire   +2 more sources

Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Postoperative Whole-Brain Radiotherapy (ESTRON)—A Single-Center Prospective Randomized Trial

, 2018
Neurosurgical resection is recommended for symptomatic brain metastases, in oligometastatic patients or for histology acquisition. Without adjuvant radiotherapy, roughly two-thirds of the patients relapse at the resection site within 24 mo, while the ...
Hauswald, Henrik, Paul, Angela, Stefan Rieken, Henrik Hauswald, Meinhard Kieser, Sebastian Klüter, Klose, Christina, Kai Schubert, Hommertgen, Adriane, Krisam, Johannes, Denise Bernhardt, Debus, Jürgen, El Shafie, Rami A., Schmitt, Daniela, Schubert, Kai, Christina Klose, Welzel, Thomas, Rami A El Shafie, Angela Paul, Johannes Krisam, Klüter, Sebastian, Jürgen Debus, Rieken, Stefan, Daniela Schmitt, Tanja Sprave, Sprave, Tanja, Thomas Welzel, Kieser, Meinhard, Bernhardt, Denise, Adriane Hommertgen   +29 more
core   +1 more source

Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study

, 2020
Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care for patients with small cell lung cancer.
Robin, Tyler P, Yomo, Shoji, Grills, Inga S, Niranjan, Ajay, Silverman, Joshua S, Aiyama, Hitoshi, Guckenberger, Matthias, Verma, Vivek, Sato, Yasunori, Singh, Charu, Combs, Stephanie, Palmer, Joshua D, Braunstein, Steve, Smith, Derek E, Lunsford, L Dade, Seto, Takahashi, Warnick, Ronald E, Attia, Albert, Yu, James B, Chiang, Veronica, Andratschke, Nicolaus, McInerney, James, Rieken, Stefan, Kavanagh, Brian D, Cifarelli, Christopher P, Sheehan, Jason P, Brown, Paul D, Chan, Michael D, Serizawa, Toru, Cordeiro, Diogo, Higuchi, Yoshinori, Day, Samuel, Kondziolka, Douglas, Deibert, Christopher P, Gao, Dexiang, Lee, Cheng-Chia, Siddiqui, Zaid A, Zacharia, Brad E, Rusthoven, Chad G, Yuan, Justin C, Li, Benjamin, Yamamoto, Masaaki, Nosaki, Kename, Kessel, Kerstin A, Patel, Samir, Trifiletti, Daniel M, Cagney, Daniel N, Shuto, Takashi, Halasz, Lia M, Touchette, Charles J, Vargo, John A, Bernstein, Kenneth, Yang, Huai-Che, Mathieu, David, Tuanquin, Leonard C, Faramand, Andrew M, Bernhardt, Denise, Aizer, Ayal A, Akabane, Atsuya   +58 more
core   +1 more source