Results 261 to 270 of about 2,879,199 (292)

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

Resolving Complex Structural Variants in Undiagnosed Rare Movement Disorders via Multimodal Genomics and Multi‐omics

Movement Disorders, EarlyView.
Abstract Background Long‐read sequencing and multi‐omic analytical frameworks are increasingly being adopted in rare disease diagnostics. However, clinical workflows comprehensively integrating these methodologies remain uncommon. Objective This study aimed to assess the potential and limitations of integrating long‐read genomic, transcriptomic, and ...
Ugo Sorrentino, Melanie Brugger, Alice Saparov, Ivana Dzinovic, Philip Harrer, Sandy Lösecke, Kevork Derderian, Martin Pavlov, Robert Kopajtich, Holger Prokisch, Arcangela Iuso, Maria Mazurkiewicz‐Bełdzińska, Deike Weiss, Christina Ludwig, Miriam Abele, Julia Mergner, Juliane Winkelmann, Theresa Brunet, Michał Schinwelski, Elisabeth Graf, Katja Kloth‐Stachnau, Theresia Herget, Magdalena Krygier, Michael Zech   +23 more
wiley   +1 more source

Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication. [PDF]

Dev Cell
Guerrero Zuniga A, Aikin TJ, McKenney C, Lendner Y, Phung A, Hook PW, Meltzer A, Timp W, Regot S.   +8 more
europepmc   +1 more source

Whole Genome Duplication Events Likely Contributed to the Aquatic Adaptive Evolution of Parkerioideae. [PDF]

Plants (Basel)
Wang M, Zhang R, Shu JP, Zheng XL, Wu XY, Chen JB, Wang MN, Shen H, Yan YH.   +8 more
europepmc   +1 more source

Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences. [PDF]

Nat Ecol Evol
Yu D, Ren Y, Uesaka M, Beavan AJS, Muffato M, Shen J, Li Y, Sato I, Wan W, Clark JW, Keating JN, Carlisle EM, Dearden RP, Giles S, Randle E, Sansom RS, Feuda R, Fleming JF, Sugahara F, Cummins C, Patricio M, Akanni W, D'Aniello S, Bertolucci C, Irie N, Alev C, Sheng G, de Mendoza A, Maeso I, Irimia M, Fromm B, Peterson KJ, Das S, Hirano M, Rast JP, Cooper MD, Paps J, Pisani D, Kuratani S, Martin FJ, Wang W, Donoghue PCJ, Zhang YE, Pascual-Anaya J.   +43 more
europepmc   +1 more source

Conserved switch genes that arose via whole-genome duplication regulate a cannibalistic nematode morph. [PDF]

Sci Adv
Wighard S, Witte H, Sommer RJ.
europepmc   +1 more source

Whole-Genome Duplication and Plant Macroevolution [PDF]

Trends in Plant Science, 2018
Whole-genome duplication (WGD) is characteristic of almost all fundamental lineages of land plants. Unfortunately, the timings of WGD events are loosely constrained and hypotheses of evolutionary consequence are poorly formulated, making them difficult to test.
James Clark, Philip Donoghue
exaly   +5 more sources

Effect of Whole-Genome Duplication on the Evolutionary Rescue of Sterile Hybrid Monkeyflowers [PDF]

Plant Communications, 2020
Hybridisation is a creative evolutionary force, increasing genomic diversity, and facilitating adaptation and even speciation. Hybrids often face significant challenges to become established, including reduced fertility arising from genomic ...
Kristyna Semberova, Danny Geelen, Nico de Storme   +2 more
exaly   +2 more sources

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Whole Genome Duplication of Intra- and Inter-chromosomes in the Tomato Genome

Journal of Genetics and Genomics, 2012
Whole genome duplication (WGD) events have been proven to occur in the evolutionary history of most angiosperms. Tomato is considered a model species of the Solanaceae family. In this study, we describe the details of the evolutionary process of the tomato genome by detecting collinearity blocks and dating the WGD events on the tree of life by ...
Juan Guo, Chi Song
exaly   +3 more sources

Polyploidy in fungi: evolution after whole-genome duplication [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2012
Polyploidy is a major evolutionary process in eukaryotes—particularly in plants and, to a less extent, in animals, wherein several past and recent whole-genome duplication events have been described. Surprisingly, the incidence of polyploidy in other eukaryote kingdoms, particularly within fungi, remained largely disregarded by the scientific community
Philippe Marullo, Warren Albertin
exaly   +4 more sources