Results 91 to 100 of about 3,777,350 (304)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Whole-Genome Sequencing in Outbreak Analysis [PDF]

Clinical Microbiology Reviews, 2015
SUMMARYIn addition to the ever-present concern of medical professionals about epidemics of infectious diseases, the relative ease of access and low cost of obtaining, producing, and disseminating pathogenic organisms or biological toxins mean that bioterrorism activity should also be considered when facing a disease outbreak.
Carol A, Gilchrist, Stephen D, Turner, Margaret F, Riley, William A, Petri, Erik L, Hewlett   +4 more
openaire   +2 more sources

The development and characterization of a 60K SNP chip for chicken [PDF]

, 2011
Background In livestock species like the chicken, high throughput single nucleotide polymorphism (SNP) genotyping assays are increasingly being used for whole genome association studies and as a tool in breeding (referred to as genomic selection).
Vereijken, Addie, Wesley C Warren, William M Muir, Hillier LaDeana W, LaDeana W Hillier, Zare Yalda, Groenen, Martien AM, Hillier, LaDeana W, Hans H Cheng, Groenen, Martin AM, Vereijken Addie, Muir William M, Zare, Yalda, Cheng, Hans H, Groenen Martien AM, Megens, H.J.W.C., Cheng Hans H, Megens Hendrik-Jan, Ron Okimoto, Vereijken, A., Muir, W.M., Martien AM Groenen, Groenen, M.A.M., Hendrik-Jan Megens, Warren Wesley C, Crooijmans, Richard PMA, Yalda Zare, Warren, W.C., Warren, Wesley C, Zare, Y., Okimoto Ron, Cheng, H.H., Richard PMA Crooijmans, Addie Vereijken, Hillier, L.W., Okimoto, Ron, Muir, Williams M, Crooijmans, R.P.M.A., Okimoto, R., Megens, Hendrik-Jan, Muir, William M, Crooijmans Richard PMA   +41 more
core   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Whole genome sequencing in Mycobacterium tuberculosis

Annals of Translational Medicine, 2019
Fighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) requires a proper and personalized use of new antitubercular drugs. To achieve this goal, the sensitivity profile to antitubercular drug should be available in a short-time and results should be highly reliable be used for patient-care.
Andrea, Spitaleri, Arash, Ghodousi, Paolo, Miotto, Daniela Maria, Cirillo   +3 more
openaire   +2 more sources

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis : a retrospective observational study [PDF]

, 2013
This study was funded by Wellcome Trust (grant number 098051), European Union (FP7 grant number 241 476), Medical Research Council, Global Alliance for TB Drug Development, and European and Developing Country Clinical Trials Partnership (grants IP.2007 ...
van Helden, Paul, Bryant, J.M., Bentley, S.D., Louw, Cheryl, Bateson, Anna L C, Boeree, M.J., Chuchottaworn, Charoen, Mahayiddin, Aziah A, Hoelscher, Michael, Gillespie, Stephen Henry, Mwaigwisya, Solomon, Parkhill, J., Bentley, Stephen D, Pym, Alex, Ahmad Mahayiddin, Aziah, Boeree, Martin J, Diacon, Andreas, Harris, Simon R, Harris, S.R., McHugh, Timothy D, Bryant, Josephine M, Chuchottaworn, C, Wright, Laura, Parkhill, Julian, Hunt, Robert D, Dawson, Rodney, Sanne, Ian M, Gillespie, Stephen H, Diacon, Andreas H   +28 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Whole‐Genome Sequencing of Yeast Cells

Current Protocols in Molecular Biology, 2019
AbstractThe budding yeast, Saccharomyces cerevisiae, has been widely used for genetic studies of fundamental cellular functions. The isolation and analysis of yeast mutants is a commonly used and powerful technique to identify the genes that are involved in a process of interest.
Rajaraman, Gopalakrishnan, Fred, Winston
openaire   +3 more sources