Results 101 to 110 of about 172,712 (267)
Towards a core genome: pairwise similarity searches on interspecific genomic data [PDF]
arXiv, 2008 The phenomenon of gene conservation is an interesting evolutionary problem related to speciation and adaptation. Conserved genes are acted upon in evolution in a way that preserves their function despite other structural and functional changes going on around them.
arxiv
Whole‐genome sequencing and the physician [PDF]
Clinical Genetics, 2012 Wybo Dondorp +3 more
openaire +4 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
An Automated System for Genome Analysis to Support Microbial Whole-genome Shotgun Sequencing [PDF]
, 2000 Tokuki Sakiyama +7 more
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Whole genome sequencing in paediatric channelopathy and cardiomyopathy
Frontiers in Cardiovascular MedicineBackgroundPrecision medicine in paediatric cardiac channelopathy and cardiomyopathy has a rapid advancement over the past years. Compared to conventional gene panel and exome-based testing, whole genome sequencing (WGS) offers additional coverage at the ...
Sit Yee Kwok +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Description of mpox reinfection by whole genome sequencing
International Journal of Infectious Diseases, 2023 Several possible mpox reinfections have been reported, however, the debate on whether these are confirmed reinfections remains open.A 30-year-old male living with HIV and a history of single-dose mpox vaccination, first diagnosed with mpox in September ...
Javier Martínez-Sanz +7 more
doaj
Mapping Challenging Mutations by Whole-Genome Sequencing
G3: Genes, Genomes, Genetics, 2016 Whole-genome sequencing provides a rapid and powerful method for identifying mutations on a global scale, and has spurred a renewed enthusiasm for classical genetic screens in model organisms. The most commonly characterized category of mutation consists
Harold E. Smith +3 more
doaj +1 more source
Gap statistics for whole genome shotgun DNA sequencing projects [PDF]
, 2004 Michael C. Wendl, Shiaw‐Pyng Yang
openalex +1 more source