Results 221 to 230 of about 567,748 (308)

Whole-genome sequencing reveals an East Asian-specific rare variant of INPP5J associated with Alzheimer's disease. [PDF]

Transl Psychiatry
Kimura T, Yamakawa A, Mitsumori R, Niida S, Ozaki K, Shigemizu D.   +5 more
europepmc   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Real-world clinical utility of tumor whole-genome sequencing in solid cancers. [PDF]

Nat Med
van Putten J, Snaebjornsson P, Bosch LJW, Koster R, Roepman P, Usset J, Boelens MC, van Wezel T, Rosenberg EH, Marchetti S, Vollebergh M, Lambregts DMJ, van der Kolk LE, Cuppen E, Nienhuis HH, Monkhorst K.   +15 more
europepmc   +1 more source

Uncovering Genomic Features and Maternal Origin of Korean Native Chicken by Whole Genome Sequencing

, 2014
Woori Kwak, Ki‐Duk Song, Jae-Don Oh, Kang–Nyeong Heo, Jun Heon Lee, Woon Kyu Lee, Sook Hee Yoon, Heebal Kim, Seoae Cho, Hak‐Kyo Lee   +9 more
openalex   +2 more sources

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Whole-genome sequencing identifies HOXD13 variants in syndactyly pedigrees. [PDF]

Hum Genomics
Xu YF, Zhang J, Wei TY, Zhang ML, Liu JE, Yang K, Tian YP, Hu HY.   +7 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

The Impact of Adopting Whole-Genome Sequencing for Tuberculosis Diagnosis in China: A Cost-Effectiveness Analysis. [PDF]

Open Forum Infect Dis
He Y, Li X, Liu C, Wong S, Fan B, Xu DR, Pagán JA, Yuan J, Yang Y, Li Y.   +9 more
europepmc   +1 more source

When Conventional Methods Fail: First Detection of a Candida viswanathii Outbreak in Europe in a Paediatric Hospital Revealed by Whole Genome Sequencing and FT-IR Spectroscopy [PDF]

Gianluca Vrenna, Valeria Fox, Venere Cortazzo, Serena Raimondi, Marco Cristiano, Gianluca Foglietta, Sara Carilli, Martina Rossitto, Barbara Lucignano, Manuela Onori, Maria Paola Ronchetti, Andrea Dotta, Andrea Campana, Lorenzo Galletti, Luca Di Chiara, Alberto Villani, Marta Luisa Ciofi degli Atti, Daniela Perrotta, Corrado Cecchetti, Massimiliano Raponi, Carlo Federico Perno, Paola Bernaschi   +21 more
openalex   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source