Results 71 to 80 of about 5,914 (256)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
The Astronomical JournalStellar systems consisting of three or more stars are not an uncommon occurrence in the Galaxy. Nearly 50% of solar-type wide binaries with separations >1000 au are actually higher-order multiples with one component being a close binary.
Zachary D. Hartman +4 more
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
White Dwarfs in Wide Binaries: The Strong Effects of Stellar Evolution and Mass Loss
The Astrophysical JournalWe examine the statistics of main-sequence/main-sequence, main-sequence/white-dwarf, and white-dwarf/white-dwarf wide binaries at 10 ^2.5 –10 ^4 au separations in Gaia data.
Hsiang-Chih Hwang, Nadia L. Zakamska
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The Astronomical JournalThe L9 dwarf SDSS J100711.74+193056.2 is situated 7 $\mathop{.}\limits^{^\circ }$ 5 north of the nearest B-type star Regulus ( d = 24.3 ± 0.2 pc), part of a stellar quadruplet.
Eric E. Mamajek, Adam J. Burgasser
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
The Astrophysical JournalWe present the first estimate of the intrinsic binary fraction of young stars across the central ≈0.4 pc surrounding the supermassive black hole (SMBH) at the Milky Way Galactic center (GC).
Abhimat K. Gautam +10 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown +6 more
wiley +1 more source