Results 51 to 60 of about 5,914 (256)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Close Encounters of Wide Binaries Induced by the Galactic Tide: Implications for Stellar Mergers and Gravitational-wave Sources

The Astrophysical Journal Letters
A substantial fraction of stars can be found in wide binaries with projected separations between ∼10 ^2 and 10 ^5 au. In the standard lore of binary physics, these would evolve as effectively single stars that remotely orbit one another on stationary ...
Jakob Stegmann, Alejandro Vigna-Gómez, Antti Rantala, Tom Wagg, Lorenz Zwick, Mathieu Renzo, Lieke A. C. van Son, Selma E. de Mink, Simon D. M. White   +8 more
doaj   +1 more source

Mergers via failed common envelope as a route toward intermediate-mass stripped stars

Astronomy & Astrophysics
Stripped stars are a common product of binary stellar systems, spanning a wide mass range from Wolf-Rayet stars to hot subdwarfs and helium white dwarfs.
Picco A., Marchant P., Pauli D., Sana H.
doaj   +1 more source

Benchmark ultra-cool dwarfs in widely separated binary systems

EPJ Web of Conferences, 2011
Ultra-cool dwarfs as wide companions to subgiants, giants, white dwarfs and main sequence stars can be very good benchmark objects, for which we can infer physical properties with minimal reference to theoretical models, through association with the ...
Jones H.R.A., Burningham B., Day-Jones A.C., Pinfield D.J., Zhang Z.H.   +4 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A High-resolution Imaging Survey of Massive Young Stellar Objects in the Magellanic Clouds

The Astrophysical Journal
Constraints on the binary fraction of massive young stellar objects (mYSOs) are important for binary and massive star formation theory. Here, we present speckle imaging of 34 mYSOs located in the Large Magellanic Cloud (1/2 Z _⊙ ) and Small Magellanic ...
Venu M. Kalari, Ricardo Salinas, Hans Zinnecker, Monica Rubio, Gregory Herczeg, Morten Andersen   +5 more
doaj   +1 more source

Stability criteria for wide binary stars harboring Oort Clouds [PDF]

Astronomy & Astrophysics, 2018
Context. In recent years, several numerical studies have been done in the field of the stability limit. Although, many of them included the analysis of asteroids or planets, is not possible to find in the literature any work on how the presence of a binary star could affect other possible configurations in a three-body problem. In order to develop this
Calandra, Maria Florencia, Correa Otto, Jorge Alfredo, Gil Hutton, Ricardo Alfredo   +2 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source