Results 31 to 40 of about 3,825,515 (243)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Pleiades Binary Fraction Revisited

The Astronomical Journal
One of the nearest and best-studied open clusters, the Pleiades is an important cornerstone of stellar astrophysics. Despite its role as a reference coeval stellar population, its multiplicity properties are still not well characterized. The combined use
Dmitry Chulkov
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Close Encounters of Wide Binaries Induced by the Galactic Tide: Implications for Stellar Mergers and Gravitational-wave Sources

The Astrophysical Journal Letters
A substantial fraction of stars can be found in wide binaries with projected separations between ∼10 ^2 and 10 ^5 au. In the standard lore of binary physics, these would evolve as effectively single stars that remotely orbit one another on stationary ...
Jakob Stegmann, Alejandro Vigna-Gómez, Antti Rantala, Tom Wagg, Lorenz Zwick, Mathieu Renzo, Lieke A. C. van Son, Selma E. de Mink, Simon D. M. White   +8 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Mergers via failed common envelope as a route toward intermediate-mass stripped stars

Astronomy & Astrophysics
Stripped stars are a common product of binary stellar systems, spanning a wide mass range from Wolf-Rayet stars to hot subdwarfs and helium white dwarfs.
Picco A., Marchant P., Pauli D., Sana H.
doaj   +1 more source

Benchmark ultra-cool dwarfs in widely separated binary systems

EPJ Web of Conferences, 2011
Ultra-cool dwarfs as wide companions to subgiants, giants, white dwarfs and main sequence stars can be very good benchmark objects, for which we can infer physical properties with minimal reference to theoretical models, through association with the ...
Jones H.R.A., Burningham B., Day-Jones A.C., Pinfield D.J., Zhang Z.H.   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Reframing the Wide Eccentric Binary Problem: Eccentricity as a Probe of Mass-transfer Physics

The Astrophysical Journal
Observations of wide postinteraction binaries show an unexpected feature: orbital eccentricity, which is not understood theoretically. A promising resolution to this long-standing puzzle is eccentric mass transfer (MT). Here, the first complete framework
A. Parkosidis, S. Toonen, E. Laplace, V. Schaffenroth   +3 more
doaj   +1 more source