Results 51 to 60 of about 6,489,977 (312)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

GetOrganelle: a fast and versatile toolkit for accurate de novo assembly of organelle genomes

open access: yesGenome Biology, 2020
GetOrganelle is a state-of-the-art toolkit to accurately assemble organelle genomes from whole genome sequencing data. It recruits organelle-associated reads using a modified “baiting and iterative mapping” approach, conducts de novo assembly, filters ...
Jian-Jun Jin   +6 more
doaj   +1 more source

The development of type VI glandular trichomes in the cultivated tomato Solanum lycopersicum and a related wild species S. habrochaites

open access: yesBMC Plant Biology, 2015
Type VI glandular trichomes represent the most abundant trichome type on leaves and stems of tomato plants and significantly contribute to herbivore resistance, particularly in the wild species.
Nick Bergau   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A fully phased octoploid strawberry genome reveals the evolutionary dynamism of centromeric satellites

open access: yesGenome Biology
We systematically examine the application of different phasing strategies to decrypt strawberry genome organization and produce a fully phased and accurate reference genome for Fragaria x ananassa cv. “EA78” (2n = 8x = 56).
Xin Jin   +5 more
doaj   +1 more source

Flavonoid scutellarin positively regulates root length through NUTCRACKER

open access: yesPlant Diversity, 2021
Exploring approaches to regulate meristem is of special importance and broad interest. In this study, we found that the flavonoid scutellarin, which has a 6-hydroxyl and a 7-glucoside, increased root length through the transcription factor NUTCRACKER ...
Xing Huang, Weiqi Li, Xudong Zhang
doaj   +1 more source

Phenolic constituents and antioxidant properties of five wild species of Physalis (Solanaceae)

open access: yesBotanical Studies, 2015
BackgroundFruits of wild species of the genus Physalis are consumed as food and calyces and leaves are used in traditional medicine. The phenolic composition of the species of this genus have been scarcely studied.
José Roberto Medina-Medrano   +5 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A near-complete genome assembly of Fragaria iinumae

open access: yesBMC Genomics
Fragaria iinumae, a diploid progenitor species of octoploid strawberries, likely occupies a basal position within the genus Fragaria. In this study, we report a near-complete genome assembly of F.
Haiyuan Du   +11 more
doaj   +1 more source

Distinct late Pleistocene subtropical-tropical divergence revealed by fifteen low-copy nuclear genes in a dominant species in South-East China

open access: yesScientific Reports, 2021
In East Asia, genetic divergence is usually considered to be correlated to different floristic regions, however, subtropical-tropical divergence is largely ignored, compared to widely explored temperate-subtropical divergence.
Jun-Wei Ye, De-Zhu Li
doaj   +1 more source

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