Results 191 to 200 of about 268,424 (252)

Homocysteine and S-adenosyl-L-homocysteine impair development and methylation in yeast and flies. [PDF]

Dis Model Mech
Brunner MS, Habisch H, Hafner J, Mack M, Novosiadla Z, López Díaz AC, Wolinski H, Rechberger GN, Eisenberg T, Madl T, Pertschy B, Kühnlein RP, Tehlivets O.   +12 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Functional profiling of 2,193 ASS1 missense variants: Insights into variant pathogenicity and epistatic interactions in citrullinemia type I. [PDF]

PLoS Genet
Lo RS, Cromie GA, Tang M, Sirr A, Caldovic L, Morizono H, Ah Mew N, Gropman A, Dudley AM.   +8 more
europepmc   +1 more source

Production of ethanol fuel from enzyme-treated sugarcane bagasse hydrolysate using d-xylose-fermenting wild yeast isolated from Brazilian biomes. [PDF]

3 Biotech, 2018
de Fátima Rodrigues de Souza R, Dutra ED, Leite FCB, Cadete RM, Rosa CA, Stambuk BU, Stamford TLM, de Morais MA.   +7 more
europepmc   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

The yeast mitochondrial porin represses Snf1/AMP kinase signaling to attenuate viral replication. [PDF]

Genetics
Chau S, Marek S, Khanna A, Sathe J, Laxman S, Meneghini MD.   +5 more
europepmc   +1 more source

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Amplicon-Based Profiling of Fungal Communities Associated with Scots Pine Bark Beetles: Selective Antagonism and Monoterpene Tolerance. [PDF]

Int J Mol Sci
Khara A, Banerjee S, Chakraborty A, Dušek J, Synek J, Roy A.   +5 more
europepmc   +1 more source

Surfactant Enhanced Bioremediation of Saline Diesel Contaminated Water by a Novel Bacterial Halophilic Consortium

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT The use of microorganisms is an evolving method for the degradation of hydrocarbon contaminants. In this aim, halophilic hydrocarbon degrading bacteria were isolated from oil contaminated soil in Tunisia. A lipopeptide biosurfactant produced by Bacillus subtilis SPB1 was tested to increase diesel biodegradation along with co‐inoculation with ...
Inès Mnif, Dhouha Ghribi
wiley   +1 more source

Cellular membranes of the related fission yeast species differ in their dipole potential. [PDF]

Biophys Rep (N Y)
Rao BD, Oliferenko S.
europepmc   +1 more source