Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Ultraviolet Technologies for Yeast Control and Functional Modulation in the Food Industry: Mechanisms, Resistance and Applications. [PDF]
FoodsZavala A +3 more
europepmc +1 more source
Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li +7 more
wiley +1 more source
Yeast-Mediated Plastic Biodegradation. [PDF]
Int J Mol SciYang XY, Xie LB, Zhang ZW, Yuan S.
europepmc +1 more source
Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications
Journal of the Chinese Chemical Society, EarlyView.This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley +1 more source
The role of <i>OLE2</i> and <i>POX1-3</i> in prostaglandin E<sub>2</sub> production and virulence is conserved in <i>Candidozyma</i> (<i>Candida</i>) <i>auris</i>. [PDF]
Microbiol SpectrBolsenbroek A +5 more
europepmc +1 more source
Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal +2 more
wiley +1 more source
Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts. [PDF]
PLoS GenetHarrison MC +9 more
europepmc +1 more source
Journal of Surfactants and Detergents, EarlyView.ABSTRACT The use of microorganisms is an evolving method for the degradation of hydrocarbon contaminants. In this aim, halophilic hydrocarbon degrading bacteria were isolated from oil contaminated soil in Tunisia. A lipopeptide biosurfactant produced by Bacillus subtilis SPB1 was tested to increase diesel biodegradation along with co‐inoculation with ...
Inès Mnif, Dhouha Ghribi
wiley +1 more source
Changing Trends in the Fungal Aetiology of Chronic Suppurative Otitis Media and Antifungal Susceptibility Patterns of Isolated Fungi: A Pilot Study From a Tertiary Care Centre in Central India. [PDF]
CureusBhadade AA +9 more
europepmc +1 more source