Results 151 to 160 of about 803,402 (308)

Prediction and Experimental Validation of the Influence of T-Stress on I–II Mixed-Mode Fracture in Rock

open access: yesAdvances in Civil Engineering
Traditional fracture criteria only consider the singular terms in the Williams expansion and neglect higher-order term coefficients, resulting in significant discrepancies between predicted and measured values.
Yongfeng Liu   +3 more
doaj   +1 more source

How do secondary schools in England talk about modern languages? A corpus‐assisted discourse analysis of school websites

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Situating the study within an ecological perspective on language education, this article examines how secondary schools in England present Modern Languages (MLs) on official school websites. Focusing on 44 schools in Local Authorities with the lowest percentage average entry for the Languages pillar of the EBacc, we built a text database ...
Zhu Hua, Yunpeng Du, Elin Arfon
wiley   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai   +9 more
wiley   +1 more source

Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan   +7 more
wiley   +1 more source

Impact of Process Interruptions in the Production of Lysates for Cell‐Free Expression Systems

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐free gene expression systems offer cell‐like functionalities outside the confines of the cell, garnering increasing interest for applications from biomanufacturing to sensing. As applications expand, the need to implement economically scaled processes to produce cellular lysates grows.
Katherine A. Rhea   +11 more
wiley   +1 more source

Protein thermal stability in the undergraduate biochemistry laboratory: Exploring protein thermal stability with yeast alcohol dehydrogenase

open access: yesBiochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 209-217, March/April 2025.
Abstract We created a novel laboratory experience where undergraduate students explore the techniques used to study protein misfolding, unfolding, and aggregation. Despite the importance of protein misfolding and aggregation diseases, protein unfolding is not typically explored in undergraduate biochemistry laboratory classes.
Alison Bates   +2 more
wiley   +1 more source

A review of the historic and present ecological role of aquatic and shoreline wood, from forest to deep sea

open access: yesBiological Reviews, EarlyView.
ABSTRACT The ecology of forests, their losses, and terrestrial wood decomposition dynamics have been intensively studied and reviewed. In the aquatic realm, reviews have concentrated on large wood (LW) in rivers and the transition from freshwater to marine environments in the Pacific Northwest of North America. However, a comprehensive global synthesis
Jon Dickson   +9 more
wiley   +1 more source

Phase II Study of Dabrafenib and Trametinib in Patients With Tumors With <i>BRAF</i><sup><i>V600E</i></sup> Mutations: Updated Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol H. [PDF]

open access: yesJCO Precis Oncol
Salama AKS   +18 more
europepmc   +1 more source

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