Results 71 to 80 of about 3,009,060 (331)
METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children
BMC Cancer, 2021 Background Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis.
Zhenjian Zhuo +13 more
doaj +1 more source
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Systemic Management of Relapse Wilms Tumor After Radical Nephrectomy in an Adult Female, a Case Report [PDF]
, 2017 Wilms tumor (nephroblastoma) is rare in adults. We present a case of 28-year old female with Wilms tumor diagnosed with pre-operative abdominal magnetic resonance imaging, histopathological analysis and immunohistochemistry.
HARAHAP, E. U. (EDWARD) +2 more
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Topotecan distribution in an anephric infant with therapy resistant bilateral Wilms tumor with a novel germline WT1 gene mutation [PDF]
, 2008 The therapeutic strategy for bilateral Wilms tumor (WT) remains a challenge. Especially in cases with chemotherapy resistant disease, bilateral nephrectomy is sometimes inevitable.
Alders, M. (Mariëlle) +5 more
core +3 more sources
Advanced Science, EarlyView.Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao +8 more
wiley +1 more source
Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]
, 2014 Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
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A Population‐Based Assessment of Cancer Risk in Children With VACTERL
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Cancer risk in children with VACTERL, a nonrandom co‐occurrence of ≥ 3 defects (vertebral, anal, cardiac, tracheoesophogeal fistula, renal, and limb), remains unclear. We evaluated this association in a population‐based study. We analyzed data from the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Study, a US registry linkage ...
Ji Yun Tark +15 more
wiley +1 more source
Urology Case ReportsTeratoid Wilms tumor is a very rare tumor, about 70 cases have been reported worldwide. Extrarenal teratoid Wilms tumor is even less common. We reported a child with sacrococcygeal teratoid Wilms tumor who was diagnosed with teratoma at the time of the ...
Xian Wei, Ting Li, Xiaojuan Wu
doaj +1 more source
Association of Wilms Tumor with Crossed Fused Renal Ectopia in Children: A Case Report
Journal of Cancer and Allied Specialties, 2023 Introduction: Wilms tumor is the most common renal malignancy in children. The occurrence of Wilms tumor with various congenital genitourinary anomalies has been reported, particularly in horseshoe kidneys, hypospadias, disorder of sexual development ...
Sajid Ali +3 more
doaj +1 more source
Adult Wilms tumor: a case of prolonged survival achieved by multimodal treatment [PDF]
, 1987 Wilms tumor is one of the most common malignant neoplasms in children. In the last 2 decades the survival rate of children with this disease has dramatically increased. However, in adults, the guideline for its management is less clear.
吉田, 修 +5 more
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