Results 51 to 60 of about 11,342 (257)
Penicillamine-Induced Membranous Nephropathy in an Adolescent with Wilson’s Disease [PDF]
, 2022 Membranous nephropathy may present in any age group. While it is one of the most common causes of adult nephrotic syndrome, it is a rare histologic entity in the paediatric population.
Ana Paula Serrão +5 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Wilson’s disease - a current approach to diagnostics and treatment. A literature review
, 2023 Introduction and purpose Wilson’s disease is a rare autosomal recessive genetic disorder of copper metabolism. Its global genetic prevalence is estimated at around 1:30 000. However, in the case of many patients, it takes a long time to make a diagnosis,
Bętkowska, Paulina +9 more
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Neurological Type Wilson’s Disease: a Case Report
, 2021 Wilson’s disease (WD) was defined in 1912 as a rare autosomal recessive disorder that leads to defective excretion of copper from the body. Normally, copper is absorbed in the small intestine by enterocytes and transported into the blood via ATP7A ...
DeLima, Marissa +4 more
core +1 more source
Advanced Functional Materials, EarlyView.Thioketal (TK) polymers are promising biomaterials due to their selective biodegradation by reactive oxygen species (ROS), but they respond slowly to physiologic doses of ROS. Here, the TK bond's pendant groups are modified to enhance the degradation of TK‐based implants both in vitro and in vivo.
Karina A. Bruce +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse +9 more
wiley +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Human Embryonic Stem Cell-Derived Wilson’s Disease Model for Screening Drug Efficacy
Cells, 2020 Human pluripotent stem cells (hPSCs) including human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (hiPSCs) have been extensively studied as an alternative cellular model for recapitulating phenotypic and pathophysiologic ...
Dongkyu Kim +13 more
doaj +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Acute Diagnosis of Wilson’s Disease in a Teenage Patient
, 2019 Wilson’s Disease, a rare autosomal recessive genetic disease, is caused by a mutation in the ATP7B enzyme gene. Without this enzyme, copper builds up in the brain, liver, and cornea causing a multitude of symptoms.
McCarthy, Ryan +3 more
core +1 more source