Results 91 to 100 of about 3,972,400 (287)
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution
Advanced Science, EarlyView.Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley +1 more source
Carcinoma metaplásico de mama, variante productor de matríz:
Oncología, 2007 El carcinoma metaplásico de mama, variante productor de matriz, se presenta con poca frecuencia. El pronóstico, en general, es malo, aunque depende de varios factores como: edad, tamaño tumoral, grado histológico, estado de los receptores hormonales ...
Sylvana Cuenca +4 more
doaj
BMC Gastroenterology, 2008 Background In Wilson disease, copper is not sufficiently excreted into bile due to the absence or malfunction of the Wilson protein copper ATPase in the excretory pathway of hepatocytes. Copper is found in sweat. It is unknown if the Wilson protein plays
Weiss Karl +4 more
doaj +1 more source
Arquivos de Neuro-Psiquiatria, 2013 Progressive lenticular degeneration, or Wilson’s disease (WD), even though being a rare condition, has major relevance in the field of movement disorders for it constitutes the first example of progressive neurologic deterioration caused by a toxic mechanism as a result of biochemical abnormality . In 1912, the British neurologist S. […].
openaire +4 more sources
Advanced Science, EarlyView.This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed +10 more
wiley +1 more source
Assessing the impact of an innovate behavioral health clinic: a retrospective cohort study
BMC PsychiatryBackground Patients experiencing a mental health crisis often present to the emergency department and are admitted to an inpatient facility for treatment.
Shaina Schwartz +9 more
doaj +1 more source
Wilson chiral perturbation theory, Wilson-Dirac operator eigenvalues and clover improvement [PDF]
, 2013 Chiral perturbation theory for eigenvalue distributions, and equivalently random matrix theory, has recently been extended to include lattice effects for Wilson fermions.
Damgaard, Poul H. +2 more
core +1 more source
Bootstrapping Null Polygon Wilson Loops
, 2011 We derive the two loop expressions for polygonal Wilson loops by starting from the one loop expressions and applying an operator product expansion. We do this for polygonal Wilson loops in R^{1,1} and find a result in agreement with previous computations.
Gaiotto, Davide +3 more
core +1 more source
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, EarlyView.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source