Results 91 to 100 of about 9,070,941 (298)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

open access: yesMolecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis   +20 more
wiley   +1 more source

Wind-Induced Response Control of High-Rise Buildings Using Inerter-Based Vibration Absorbers

open access: yesApplied Sciences, 2019
The beneficial mass-amplification effect induced by the inerter can be conveniently used in enhanced variants of the traditional Tuned Mass Damper (TMD), namely the Tuned Mass-Damper-Inerter (TMDI) and its special case of Tuned Inerter Damper (TID).
Qinhua Wang   +4 more
doaj   +1 more source

Dynamic response of temporary structures due to wind loading

open access: yes, 2015
Due to the lack of an international standard for the design of temporary stage structures, there have been several instances where temporary stage structures have failed and resulted in injury or death during strong wind events (Tomasetti, 2012).
Bishay, A. (x)   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Wind-Resistant Configuration of Double-Layer Cable-Supported Flexible Photovoltaic Array Based on Interference Effect Analysis

open access: yesEnergies
This study investigates the wind-resistant configuration of a seven-row single-span double-layer cable-supported photovoltaic (PV) array through conducting systematic analysis of the interference effect.
Yi Tang   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

The effect of wind-induced building motion in a longitudinal sample of office workers in Wellington, New Zealand

open access: yes, 2015
47 office workers located on high floors and 53 office workers on or near the ground floor in Wellington, New Zealand, completed 1,909 short online surveys across a period of 8 months.
Lamb, Steven (R18264)   +2 more
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Human perception of wind-induced tall building motions

open access: yes, 2006
In addition to strength and safety requirements, wind-induced building motion can interfere with building occupants’ daily activities and hence occupant comfort is a critical design consideration, particularly for tall and slender buildings constructed ...
Kwok, Kenny C. S.   +2 more
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

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