Results 101 to 110 of about 463,017 (306)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Wind-Induced Response Analysis of Double Layer Cylindrical Lattice Shells

, 2011
Analysis of wind-induced response of double-layer cylindrical reticulated shell by different methods of calculation . The results showed that the wind-induced response of the structure was increased and too safety by using existing load code calculation.
Min Li, Yong Yao, Jion Yang
core   +1 more source

Microtab dynamic modelling for wind turbine blade load rejection [PDF]

, 2014
A dynamic model characterising the effect of microtab deployment on the aerodynamics of its base aerofoil is presented. The developed model predicts the transient aerodynamic coefficients consistent with the experimental and computational data reported ...
Busawon, Krishna, Macquart, Terence, Maheri, Alireza   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Study on Wind Vibration Response and Coupling Effect of Transmission Tower-Line System Under Downburst

IEEE Access
Downburst is a type of near-surface short-term destructive strong wind that significantly affects wind-sensitive flexible structures like transmission tower-line systems.
Yongli Zhong, Yichen Liu, Shun Li, Zhitao Yan, Xinpeng Liu   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Amended Draft Response Plan

, 2014
August 27, 2014 To: Induced Seismicity Stakeholder Group From: Rex Buchanan, Interim Director, Kansas Geological Survey Mike Tate, Chief, Bureau of Water, Dept.
Kansas Induced Seismicity State Task Force.
core  

Wind-induced vibrations of structures : with special reference to tall building aerodynamics

, 2013
This chapter examines the wind-induced vibrations of buildings and structures. In particular, the alongwind and the crosswind excitation mechanisms and response processes are discussed.
Kenny C. S. Kwok, Kwok, Kenny C. S. (R14040)   +1 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A study of the statistical approach to wind loading

, 1975
Includes bibliographical references.This study is concerned with the prediction of the maximum probable response of structures in the along-wind direction.
Watson, Bjorn Hugh Henry
core