Results 121 to 130 of about 9,070,941 (298)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Structural Response Analysis and Comfort Evaluation of Residential Buildings: A Combined Wind Tunnel and FEM Approach

Buildings
With global urbanization accelerating, high-rise buildings have become a common feature in the urban landscape, especially in coastal cities, where they encounter unique wind-load challenges.
Xinxin Zhang, Xiang Yuan Zheng, Kun Lin
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Physics‐Informed Neural Networks for Modeling the Martian Induced Magnetosphere

Geophysical Research Letters
Understanding the magnetic field environment around Mars and its response to upstream solar wind conditions provide key insights into the processes driving atmospheric ion escape.
Jiawei Gao, Chuanfei Dong, Chi Zhang, Yilan Qin, Simin Shekarpaz, Xinmin Li, Liang Wang, Hongyang Zhou, Abigail Tadlock   +8 more
doaj   +1 more source

A Simplified Sequential Coupled Simulation Framework for Floating Offshore Wind Turbines: A Case Study of a 15 MW TLP Turbine

Journal of Marine Science and Engineering
Tension-leg platform (TLP) horizontal-axis wind turbines (TLP-HAWTs) have become increasingly important in deep-water offshore wind energy development. However, their performance is strongly affected by coupled platform motions induced by wind and wave ...
Hongda Zhang, Rui Zhang, Shuyu Yan, Le Qi, Yong Wang, Jinbo Chen, Yan Bao, Hongbo Zhu   +7 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Combination of High- and Low-Rate GPS Receivers for Monitoring Wind-Induced Response of Tall Buildings. [PDF]

Sensors (Basel), 2018
Yi Z, Kuang C, Wang Y, Yu W, Cai C, Dai W.   +5 more
europepmc   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Effects of wind-induced tall building vibrations on a tracking task

, 2013
Motion simulator experiments were conducted to study tracking task performances in 12 low frequency fore-aft sinusoidal motion conditions that comprise low, medium and high acceleration amplitudes (8, 16 and 30 mG) and 4 frequencies 0 .125, 0.25, 0.5 and
Hau, Chui Luen Vera, Wong, Kwok-Shing (S30923), Kwok, Kenny C. S. (R14040)   +2 more
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