Results 111 to 120 of about 2,432,321 (304)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Quarter-Century Offshore Winds from SSM/I and WRF in the North Sea and South China Sea

Remote Sensing, 2016
We study the wind climate and its long-term variability in the North Sea and South China Sea, areas relevant for offshore wind energy development, using satellite-based wind data, because very few reliable long-term in-situ sea surface wind observations ...
Charlotte Bay Hasager, Poul Astrup, Rong Zhu, Rui Chang, Merete Badger, Andrea N. Hahmann   +5 more
doaj   +1 more source

Magnetospheric Cavity Modes Driven by Solar Wind Dynamic Pressure Fluctuations

, 2010
We present results from Lyon-Fedder-Mobarry (LFM) global, three-dimensional magnetohydrodynamic (MHD) simulations of the solar wind-magnetosphere interaction.
Han, Jacobs, Kepko, Kivelson, Korotova, Lyon, M. K. Hudson, M. Wiltberger, Matsuoka, S. G. Claudepierre, S. R. Elkington, Sibeck, Viall, W. Lotko, Wiltberger, Wright   +15 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The pick-up of cometary protons by the solar wind [PDF]

The High Energy Range Spectrometer (HERS) of the Ion Mass Spectrometer on the Giotto spacecraft measured the 3-dimensional distribution of picked-up cometary protons over a distance of approximately 8 million km upstream of the bow shock of Comet Halley.
eated solar wind protons., eated solar wind protons., Neugebauer, M.   +2 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Analysis of Extreme Wind Pressure Based on Extreme Value Distribution Theory

Atmosphere
When extreme wind pressure is predicted based on the extreme value distribution theory, the sampling time–distance and sample volume of wind pressure data are important influencing factors. To discuss and analyze the influence of time–distance and sample
Weihu Chen, Yuji Tian, Fan Bai
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Theoretical and numerical approach for quantifying sensitivity to system parameters of nonlinear systems

Nonlinear Engineering
Sensitivity evaluation of nonlinear systems to system parameters is critically important in nonlinear dynamics, though current focuses in the field are mainly on the sensitive dependence of nonlinear systems upon initial conditions.
Xia Dandan, Dai Liming
doaj   +1 more source