Results 71 to 80 of about 1,211,534 (340)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Comparison of Large Eddy Simulations of a convective boundary layer with wind LIDAR measurements [PDF]
Advances in Science and Research, 2012 Vertical profiles of the horizontal wind speed and of the standard deviation of vertical wind speed from Large Eddy Simulations of a convective atmospheric boundary layer are compared to wind LIDAR measurements up to 1400 m. Fair agreement regarding both
J. G. Pedersen +5 more
doaj +1 more source
Wind Energy Resource Base and Incentives [PDF]
, 2006 Key facts: - At the beginning of 2006, the U.S. wind industry has a total generating capacity of 9,149 MW. - In 2005, the U.S. wind energy industry installing nearly 2,500 megawatts (MW) or over $3 billion worth of new generating equipment in 22 states ...
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Spectral signature of a free pulsar wind in the gamma-ray binaries LS 5039 and LSI +61$\degr$303 [PDF]
, 2008 LS 5039 and LSI +61$\degr$303 are two binaries that have been detected in the TeV energy domain. These binaries are composed of a massive star and a compact object, possibly a young pulsar.
Aharonian +35 more
core +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Comparison between upwind and downwind designs of a 10 MW wind turbine rotor [PDF]
Wind Energy Science, 2019 The size of wind turbines has been steadily growing in the pursuit of a lower cost of energy by an increased wind capture. Within this trend, the vast majority of wind turbine rotors have been designed based on the conventional three-bladed upwind ...
P. Bortolotti, A. Kapila, C. L. Bottasso
doaj +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Turbulence characterization from a forward-looking nacelle lidar [PDF]
Wind Energy Science, 2017 We present two methods to characterize turbulence in the turbine inflow using radial velocity measurements from nacelle-mounted lidars. The first uses a model of the three-dimensional spectral velocity tensor combined with a model of the spatial ...
A. Peña, J. Mann, N. Dimitrov
doaj +1 more source