Results 101 to 110 of about 102,683 (311)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Effect of tip vortices on flow over NACA4412 aerofoil with different aspect ratios
EPJ Web of Conferences, 2016 Effect of tip vortices on flow and laminar separation bubble over NACA4412 aerofoil at low Reynolds numbers and different angles of attack was investigated in detail by performing force and flow visualization via smoke wire technique.
Genç Mustafa Serdar +4 more
doaj +1 more source
Wind Tunnel transient aerodynamic performance testing of a small wind turbine
, 2016 During the last years, the widespread development of wind systems has pushed the interest in producing energy also through a distributed multitude of small wind turbines installed in urban areas.
Francesco Castellani +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Effect of tip vortices on membrane vibration of flexible wings with different aspect ratios
EPJ Web of Conferences, 2016 In this study, the effect of the aspect ratio on the aerodynamics characteristic of flexible membrane wings with different aspect ratios (AR = 1 and AR = 3) is experimentally investigated at Reynolds number of 25000.
Genç Mustafa Serdar +5 more
doaj +1 more source
Active generation of large scale turbulence in a boundary layer wind tunnel
, 2003 The effect of turbulence on bluff body aerodynamics and response in wind flow has been increasingly studied for a wide range of turbulence integral scale.
Cheung, John C. K. +2 more
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Advanced structural wind engineering
, 2013 This book serves as a textbook for advanced courses as it introduces state-of-the-art information and the latest research results on diverse problems in the structural wind engineering field. The topics include wind climates, design wind speed estimation,
Kareem, Ahsan, Tamura, Yukio
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Wind Engineering Australia: Monash report 2004
, 2004 This paper is to provide information on the current wind engineering research and activities being carried out in Australia at Monash University by MEL consultants in anticipation for Regional Harmonization of Wind Loading and Wind Environmental ...
Cheung, John C. K. +1 more
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