Results 61 to 70 of about 49,771 (264)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Examination of wind speed based on field measurements on a low-rise building
Frontiers in Built EnvironmentMean and peak wind speeds, as well as gust factors, integral scales, and intensity of turbulence values, are essential in formulating wind loading standards for structures.
Shuoqi Wang +5 more
doaj +1 more source
Effect of tip vortices on membrane vibration of flexible wings with different aspect ratios
EPJ Web of Conferences, 2016 In this study, the effect of the aspect ratio on the aerodynamics characteristic of flexible membrane wings with different aspect ratios (AR = 1 and AR = 3) is experimentally investigated at Reynolds number of 25000.
Genç Mustafa Serdar +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Computation, 2015 The motivation of this work is to bridge the gap between experimental approaches in wind tunnel testing and numerical computations, in the field of structural design against strong winds.
Julien Berthaut-Gerentes +1 more
doaj +1 more source
Knowledge Engineering for Wind Energy
Wind Energy ScienceAbstract. With the rapid evolution of the wind energy sector, there is an ever-increasing need to create value from the vast amounts of data made available both from within the domain, as well as from other sectors. This article addresses the challenges faced by wind energy domain experts in converting data into domain knowledge, connecting and ...
Y. Marykovskiy +11 more
openaire +7 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Coupled Finite Volume and Finite Element Method Analysis of a Complex Large-Span Roof Structure
International Journal of Applied Mechanics and Engineering, 2017 The main goal of this paper is to present coupled Computational Fluid Dynamics and structural analysis for the precise determination of wind impact on internal forces and deformations of structural elements of a longspan roof structure. The Finite Volume
J. Szafran, K. Juszczyk, M. Kamiński
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source