Results 121 to 130 of about 66,305 (312)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Wind Power Development: Opportunities and Challenges [PDF]
In this study, the prospects of wind power at the global level are reviewed. Existing studies indicate that the earth’s wind energy supply potential significantly exceeds global energy demand.
Govinda R. Timilsina +1 more
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Wind Structure and Wind Loading
, 2007 The purpose of this note is to provide a short description of wind, i.e. of the flow in the atmosphere of the Earth and the loading caused by wind on structures. The description comprises:causes to the generation of windhe interaction between wind and the surface of the Earthhe stochastic nature of windhe interaction between wind and structures, where ...
openaire +1 more source
The Astrophysical Journal, 1996 This paper explores the steady state behavior of mass-loaded winds. The topology of the critical point that results from the slowing of the wind is a function of the local slope of the mass-loading function. Mass-loading functions that increase sufficiently rapidly with radius as well as gravitational force can cause the steady state approximation to ...
openaire +1 more source
Applicability study of rules for wind load calculation of FPSO based on CFD
Zhongguo Jianchuan YanjiuObjective At present, the oil companies international marine forum (OCIMF) rules are frequently used to calculate wind load for large tankers and the American petroleum institute (API) rules for offshore platforms.
Yang MIAO +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Aerodynamic Design of Wind Turbine Blades Utilising Nonconventional Control Systems
As a result of the significant growth of wind turbines in size, blade load control has become the main challenge for large wind turbines. Many advanced techniques have been investigated aiming at developing control devices to ease blade loading ...
Wiratama, I. Kade
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, 2013 Presented in this paper are the results of numerical simulation of bushfire enhanced wind and its impact on buildings of various shapes. Using an extended computation domain, the velocity and pressure fields around three buildings which are exposed to ...
Kwok, Kenny C. S. (R14040) +4 more
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