Results 41 to 50 of about 31,789 (263)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Identification of Wind Load Exerted on the Jacket Wind Turbines from Optimally Placed Strain Gauges Using C-Optimal Design and Mathematical Model Reduction

Journal of Marine Science and Engineering
Wind turbine towers experience complex dynamic loads during actual operation, and these loads are difficult to accurately predict in advance, which may lead to inaccurate structural fatigue and strength assessment during the structural design phase ...
Fan Zhu, Meng Zhang, Fuxuan Ma, Zhihua Li, Xianqiang Qu   +4 more
doaj   +1 more source

Numerical wind load estimation of offshore floating structures through sustainable maritime atmospheric boundary layer

International Journal of Naval Architecture and Ocean Engineering, 2020
Wind load is one of the major design loads for the hull and mooring of offshore floating structures, especially due to much larger windage area above water than under water.
Seong Mo Yeon, Joo-Sung Kim, Hyun Joe Kim   +2 more
doaj   +1 more source

Wind tunnel test study on the wind load variation law of a point focus solar furnace

Frontiers in Energy Research, 2023
This work studied the wind load acting on a point focus solar furnace composed of a 110 m2 heliostat and a 77 m2 concentrator through wind tunnel testing.
Mingfei He, Mingfei He, Mingfei He, Mingfei He, Penglin Huang, Penglin Huang, Penglin Huang, Penglin Huang, Bo Gong, Bo Gong, Bo Gong, Bo Gong, Chuncheng Zang, Chuncheng Zang, Chuncheng Zang, Chuncheng Zang, Zhifeng Wang, Zhifeng Wang, Zhifeng Wang, Zhifeng Wang   +19 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The analysis of dynamic characteristics and wind-induced displacement response of space Beam String Structure

E3S Web of Conferences, 2018
The Beam String Structure structural system, also called BSS, has the advantages of lighter dead weight and greater flexibility. The wind load is the main design control factor.
Chen Yong Jian, Feng Zhen Fa, Qi Ai, Huang Ying   +3 more
doaj   +1 more source

Predictions for Bending Strain at the Tower Bottom of Offshore Wind Turbine Based on the LSTM Model

Energies, 2023
In recent years, the demand and requirement for renewable energy have significantly increased due to concerns regarding energy security and the climate crisis. This has led to a significant focus on wind power generation.
Songjune Lee, Seungjin Kang, Gwang-Se Lee   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Performance and Effect of Load Mitigation of a Trailing-Edge Flap in a Large-Scale Offshore Wind Turbine

Journal of Marine Science and Engineering, 2020
As a result of the large-scale trend of offshore wind turbines, wind shear and turbulent wind conditions cause significant fluctuations of the wind turbine’s torque and thrust, which significantly affect the service life of the wind turbine gearbox
Xin Cai, Yazhou Wang, Bofeng Xu, Junheng Feng   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source