Results 61 to 70 of about 31,789 (263)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The impact of far-reaching offshore cluster wakes on wind turbine fatigue loads [PDF]
Wind Energy ScienceWith the number of commissioned and planned wind farms increasing rapidly, analysing wind farm cluster wakes becomes essential for resource assessment and lifetime considerations.
A. Anantharaman +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Applied SciencesThis study focuses on quantifying wind–temperature load combination coefficients for long-span hybrid cable-stayed suspension bridges (HCSSBs) to overcome limitations of traditional methods in ignoring load correlation and geometry nonlinearity.
Yuzhe Wu +3 more
doaj +1 more source
The Astrophysical Journal, 1996 This paper explores the steady state behavior of mass-loaded winds. The topology of the critical point that results from the slowing of the wind is a function of the local slope of the mass-loading function. Mass-loading functions that increase sufficiently rapidly with radius as well as gravitational force can cause the steady state approximation to ...
openaire +1 more source
Large Telescope Wind Loading [PDF]
International Astronomical Union Colloquium, 1984 One important large telescope design study area is the dynamic image degradation caused by wind forces upon various telescope structures and optical elements. The need to establish rapid thermal equilibration with the observatory environment further complicates the wind exposure problem.
openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Study on wind load characteristics of stadium under tornado. [PDF]
Sci Rep, 2023 Yuan Z, Zhang Z, Tang H.
europepmc +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source