Results 61 to 70 of about 3,828,803 (394)

Predicting wind turbine blade loads using vorticity transport and RANS methodologies [PDF]

open access: yes, 2009
Two computational methods, one based on the solution of the vorticity transport equation, and a second based on the solution of the Reynolds-Averaged Navier-Stokes equations, have been used to simulate the aerodynamic performance of a horizontal axis ...
Brown, Richard   +3 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

METHOD OF PROCESSING THE WIND TURBINE TIME HISTORY LOADS BASED ON 6 DEGREES OF FREEDOM

open access: yesJixie qiangdu, 2021
A method of simply wind turbine time history loads have been studied in the article,it can be converted the time history loads into some number of load duration distribution. It is based on the standard of ISO6336 by considering 6 degrees of freedom. The
LI JinKu, LIU Wei
doaj  

Structural Improvements for Tall Buildings under Wind Loads: Comparative Study

open access: yes, 2017
The behavior of a very slender building is investigated under wind loads, to satisfy both strength and serviceability (comfort) design criteria. To evaluate the wind effects, wind tunnel testing and structural analysis were conducted, by two different ...
Nicola Longarini   +4 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Coupled wind-induced responses and equivalent static wind loads on long-span roof structures with the consistent load–response–correlation method

open access: yes, 2018
Long-span roof structures with multiple vibration modes may undergo coupled motions when exposed to spatiotemporally varying dynamic wind loads. This article presents a framework for the analysis of coupled wind-induced responses and equivalent static ...
Nan Luo, Hong-yu Jia, H. Liao
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Experimental Investigation of Local Wind Effects on Façade Scaffolding Structures

open access: yesApplied Sciences
Wind is one of the main environmental loads acting on temporary scaffolding structures, yet current design codes apply simplified assumptions regarding its distribution.
Paulina Jamińska-Gadomska   +1 more
doaj   +1 more source

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