Results 101 to 110 of about 4,037,937 (347)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Iron charge states observed in the solar wind [PDF]

open access: yes, 1983
Solar wind measurements from the ULECA sensor of the Max-Planck-Institut/University of Maryland experiment on ISEE-3 are reported. The low energy section of approx the ULECA sensor selects particles by their energy per charge (over the range 3.6 keV/Q to
Galvin, A. B.   +5 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

On the theory of SODAR measurement techniques (final reporting on WP1, EU WISE project NNE5-2001-297) [PDF]

open access: yes, 2003
The need for alternative means to measure the wind speed for wind energy purposes has increased with the increase of the size of wind turbines. The cost and the technical difficulties for performing wind speed measurements has also increased with the ...
Antoniou, I   +6 more
core   +1 more source

Heavy rainfall, floods, and flash floods influenced by high-speed solar wind coupling to the magnetosphere–ionosphere–atmosphere system

open access: gold, 2021
Paul Prikryl   +5 more
openalex   +1 more source

Wind Speed Prediction with Spatio–Temporal Correlation: A Deep Learning Approach

open access: yes, 2018
Wind speed prediction with spatio–temporal correlation is among the most challenging tasks in wind speed prediction. In this paper, the problem of predicting wind speed for multiple sites simultaneously is investigated by using spatio–temporal ...
Q. Zhu   +4 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

Flow field analysis [PDF]

open access: yes
The average mean wind speed integrated over a disk is shown to be extremely close to the mean value of wind speed which would be measured at the center of a disk for most geometries in which a WECS (Wind Energy Conversion System) would operate.
Cliff, W. C., Verholek, M. G.
core   +1 more source

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