Results 101 to 110 of about 3,189,300 (321)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Fully-coupled modeling and analysis of the influence of anti-icing bleed air system of engine inlet duct on compressor performance

Case Studies in Thermal Engineering
A fully-coupled method that integrates the compressor, inlet duct and anti-icing bleed air system (AI-BAS) was established to offer a quick prediction of the effects of anti-icing bleeding on compressor performance, facilitating the development of a ...
Zuojun Wei, Cheng Li, Guangming Ren, Xiaohua Gan   +3 more
doaj  

Observation analysis of wind climate in China for 1971–2017 under the demand of wind energy evaluation and utilization

Energy Reports, 2021
To meet the requirement of the wind energy resource assessment and utilization, the statistical characteristics of wind climate in the China mainland were analyzed in this study by using observation wind dataset for 1971–2017 from the China ...
Zhenyu Li, Zi-niu Xiao, Chong-wei Zheng
doaj  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Assessment of wind energy potential based on Weibull and Rayleigh distribution models

Energy Reports, 2020
The present study aims to analyze the wind power potential in two locations in Galati county, Romania, before making a decision on the appropriate area for wind turbine installation.
Alexandru Serban, Lizica Simona Paraschiv, Spiru Paraschiv   +2 more
doaj  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Band Depth Clustering for Nonstationary Time Series and Wind Speed Behavior [PDF]

arXiv, 2015
We explore the behavior of wind speed over time, using the Eastern Wind Dataset published by the National Renewable Energy Laboratory. This dataset gives wind speeds over three years at hundreds of potential wind farm sites. Wind speed analysis is necessary to the integration of wind energy into the power grid; short-term variability in wind speed ...
arxiv  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

The optimal wind speed product selection for wind energy assessment under multi-factor constraints

Cleaner Engineering and Technology
Wind energy is an important part of sustainable energy. Potential assessment of wind energy, based on an appropriate wind speed dataset, is crucial for wind energy development.
Xiaohui Li, Yunhao Chen, Kangning Li, Shengjun Gao, Ying Cui   +4 more
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source