Results 71 to 80 of about 437,935 (290)

IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment

OncoImmunology, 2019
Ovarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorganisms and has a unique immune environment.
Alfredo Perales-Puchalt, Nikolaos Svoronos, Daniel O. Villarreal, Urvi Zankharia, Emma Reuschel, Krzysztof Wojtak, Kyle K. Payne, Elizabeth K. Duperret, Kar Muthumani, Jose R. Conejo-Garcia, David B. Weiner   +10 more
doaj   +1 more source

Can Viruses be Modified to Achieve Sustained Gene Transfer?

Frontiers in Microbiology, 2011
It is very easy to replace a faulty gene in an immunocompromised mouse. First, one takes a well-characterized virus, such as an adenovirus or an adeno-associated virus, and incorporates the correct version of the faulty gene together with some regulatory
Hildegund CJ Ertl, Hua eLi
doaj   +1 more source

Pre-clinical modeling of cutaneous melanoma

Nature Communications, 2020
Despite the new targeted and immunotherapies for metastatic melanoma, several patients show therapeutic plateau. Here, the authors review the current pre-clinical models of cutaneous melanoma and discuss their strengths and limitations that may help with
Vito W. Rebecca, Rajasekharan Somasundaram, Meenhard Herlyn   +2 more
doaj   +1 more source

Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]

, 2019
Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe, De Saeger, Sarah, Li, Yanshen, Li, Yi, Rao, Zhenghua, Sun, Feifei, Tan, Haiguang, Yang, Shupeng, Zhang, Huiyan, Zhou, Jinhui   +9 more
core   +1 more source

Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus

Animal Models and Experimental Medicine, EarlyView.
Adropin is related to the energy homeostasis‐associated gene. It significantly increased glutathione reductase enzyme levels in the pancreas of experimental diabetic rats. Adropin may reduce the severity of diabetes and its complications. Cell proliferation in the exocrine is reduced after the administration of adropin.
Ifrah I. Ali, Crystal D'Souza, Abderrahim Nemmar, Shreesh Ojha, Ernest A. Adeghate   +4 more
wiley   +1 more source

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat II: chronic dosing causes developmental delay [PDF]

, 2007
We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat, using chronically exposed rats to ensure continuous exposure of the fetus. 5-6 week old rats were exposed
Bell, David Robert, Clode, Sally, Fan, MingQi, Fernandes, Alwyn, Foster, Paul M D, Jiang, tao, Loizou, George, MacNicoll, Alan, Miller, Brian G, Rose, Martin, Tran, Lang, White, Shaun   +11 more
core   +1 more source

New high-performance liquid chromatography-dad method for analytical determination of arbutin and hydroquinone in rat plasma [PDF]

, 2015
Natural substances present in herbal preparations should be carefully used because they can give toxic or therapeutic effects despite of their amount or the way of administration.
Altieri, I., D'Amore, E., Gallo, F. R., Multari, G., PAGLIUCA, GIORDANA, Panzini, G.   +5 more
core   +2 more sources

Characterization of di‐gital, tri‐gital, and tetra‐gital temporal movement of systolic blood pressure on the arterial pulse waveform of rats at different vascular stiffness

Animal Models and Experimental Medicine, EarlyView.
The example of the time dependent fluctuation of systolic pressure on rat arterial pulse waveform in ms. The four levels of the systolic pressure fluctuation show di‐gital, tri‐gital and tetra‐gital fluctuation. The red dots represent particular heartbeats. Abstract Background An arterial stiffness is an indicator of many cardiovascular diseases.
Anton Misak, Lenka Tomasova, Marian Grman, Karol Ondrias   +3 more
wiley   +1 more source

ZSF1 lean rats – How healthy are they?

Animal Models and Experimental Medicine, EarlyView.
This study aimed to examine the health status, specifically the physiology and myocardial, vascular, and skeletal muscle function of lean ZSF1 rats by comparing them to age‐ and sex‐matched Wistar rats. Compared to Wistar controls, ZSF1 lean rats exhibited lower body weight, but showed increased heart, and skeletal muscle mass.
Antje Schauer, Beatrice Vahle, Volker Adams, Axel Linke, Antje Augstein   +4 more
wiley   +1 more source

Padronização de modelo experimental adequado a estudos do efeito do exercício na artrite

Einstein (São Paulo)
OBJETIVO: Padronizar um modelo experimental de monoartrite crônica induzida por adjuvante completo de Freund apropriado à análise do efeito da deambulação na nocicepção e no edema articular. MÉTODOS: Foram avaliados os seguintes fatores para a indução da
Raquel Pinheiro Gomes, Elisangela Bressan, Tatiane Morgana da Silva, Monique da Silva Gevaerd, Carlos Rogério Tonussi, Susana Cristina Domenech   +5 more
doaj   +1 more source