IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment
OncoImmunology, 2019 Ovarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorganisms and has a unique immune environment.
Alfredo Perales-Puchalt +10 more
doaj +1 more source
“Tempe” Reduces Dna Damage in Rats Irradiated with Ultraviolet Ray [PDF]
, 2011 ‘Tempe' is a popular Javanese-Indonesian tradisional food made of fermentedsoyabean. This study aims to examine whether ‘tempe', used as a strong anti-free,has the ability to decrease DNA damage induced by ultraviolet ray irirradiation inthe Wistar rats ...
Agus Bagiada, I Nyoman +3 more
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Short-term therapy with rosiglitatzone, a PPAR-¿ agonist improves metabolic profile and vascular function in non-obese lean wistar rats [PDF]
, 2012 A number of preclinical and clinical studies have reported blood-pressure-lowering benefits of thiazolidinediones in diabetic subjects and animal models of diabetes.
Abubakari, Abdul-Razak +3 more
core +1 more source
Advanced Materials Technologies, EarlyView.Hydrogel‐forming microneedle patches are developed using shape‐preserving PVA‐PVP hydrogels, with and without chitosan, for minimally invasive transdermal protein biomarker sampling. The optimised patches enable efficient interstitial fluid uptake and proteomic analysis, while minimising interference.
Achmad Himawan +12 more
wiley +1 more source
Pre-clinical modeling of cutaneous melanoma
Nature Communications, 2020 Despite the new targeted and immunotherapies for metastatic melanoma, several patients show therapeutic plateau. Here, the authors review the current pre-clinical models of cutaneous melanoma and discuss their strengths and limitations that may help with
Vito W. Rebecca +2 more
doaj +1 more source
The effects of sildenafil ciltrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus)- A histological study [PDF]
, 2010 The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely the lateral geniculate body (LGB) of adult Wistar rat ...
Eweka, A, Eweka, AO
core +1 more source
When Cellulose Moves: Smart Sensors and Actuators
Advanced Materials Technologies, EarlyView.This review highlights cellulose‐derived soft actuators alongside with cellulose‐based sensors. Emphasis is placed on their integration into multifunctional devices that couple sensing and actuation to mimic natural motion and adaptability. We also discuss the challenges of achieving robust, reversible, and multi‐stimuli‐responsive motion, and outline ...
Francisco Sousa +2 more
wiley +1 more source
Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]
, 2019 Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe +9 more
core +1 more source
Fear conditioning fragments REM sleep in stress-sensitive Wistar–Kyoto, but not Wistar, rats [PDF]
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011 Pavlovian conditioning is commonly used to investigate the mechanisms of fear learning. Because the Wistar-Kyoto (WKY) rat strain is particularly stress-sensitive, we investigated the effects of a psychological stressor on sleep in WKY compared to Wistar (WIS) rats.
Richard J. Ross +7 more
openaire +3 more sources
Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis
Advanced Science, EarlyView.This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang +10 more
wiley +1 more source