Results 151 to 160 of about 3,494 (215)

Ashwagandha (Withania somnifera) targets liver cancer stem cells via inhibiting Hedgehog signaling pathway in hepatocellular carcinoma. [PDF]

Med Oncol
Ismail SE, Youssef AI, Fawzy EE, Khalifa EA, Kazem AH, Kholief MA, Saleh ZA.   +6 more
europepmc   +1 more source

Subfunctionalization and epigenetic regulation of a biosynthetic gene cluster in <i>Solanaceae</i>. [PDF]

Proc Natl Acad Sci U S A
Priego-Cubero S, Knoch E, Wang Z, Alseekh S, Braun KH, Chapman P, Fernie AR, Liu C, Becker C.   +8 more
europepmc   +1 more source

Dual targeting of IGF-1R and K-RAS with natural phytochemicals for lung cancer therapy: an in-silico study. [PDF]

J Genet Eng Biotechnol
Ahmed SF, Hossen Z, Chakraborty I, Rahman Munna MM, Chowdhury S, Zaheen A, Tasmin J, Ashraful ABM, Jahin MA, Ahmed MH.   +9 more
europepmc   +1 more source

Natural compounds as therapeutic candidates for spinocerebellar ataxia type 1: a computational approach. [PDF]

In Silico Pharmacol
Singh S, Singh S, Joshi D, Mohanty C, Singh R.   +4 more
europepmc   +1 more source

Withanolide Z, a New Chlorinated Withanolide fromWithania somnifera

Planta Medica, 2008
Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5).
Swapan, Pramanick, Amit, Roy, Shekher, Ghosh, Hemanta K, Majumder, Sibabrata, Mukhopadhyay   +4 more
openaire   +3 more sources

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Natural withanolides, an update

Natural Product Reports, 2022
This review summarizes the research progress on the structural classification, biological activities and mechanisms, metabolism and pharmacokinetic investigations, biosynthesis, and synthesis and structural modifications of the withanolides.
Gui-yang Xia, Shi-jie Cao, Li-xia Chen, Feng Qiu   +3 more
openaire   +2 more sources

Withanolides from Discopodium penninervium

Fitoterapia, 2023
Discopodium penninervium is a medicinal plant endemic to Ethiopia. Its twigs extract led to the isolation of three new withanolides, discopodinolides A - C, and four known analogues. The structures of the compounds were elucidated using NMR, HRMS data analyses, and literature data.
Kibrom Gebreheiwot, Bedane, Mekonnen Abebayehu, Desta, Peter, Spiteller   +2 more
openaire   +2 more sources

Natural withanolides: an overview

Natural Product Reports, 2011
Withanolides are a group of naturally occurring C28 steroids built on an ergostane skeleton functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. Over the period of August 1996 to March 2010, 360 new naturally occurring withanolides were isolated and identified.
Li-Xia, Chen, Hao, He, Feng, Qiu
openaire   +2 more sources

Trypanocidal Withanolides and Withanolide Glycosides from Dunalia brachyacantha

Journal of Natural Products, 2001
Two new withanolide glycosides, (20R,22R)-O-(3)-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl-1 alpha,12 beta-diacetoxy-20-hydroxywitha-5,24-dienolide (3) and (20R,22R)-O-(3)-beta-D-xylopyranosyl(1-->3)-[beta-D-xylopyranosyl(1-->4)]-beta-D-glucopyranosyl-1 alpha-acetoxy-12 beta,20-dihydroxywitha-5,24-dienolide (4), were isolated from the leaves ...
J A, Bravo B, M, Sauvain, A, Gimenez T, E, Balanza, L, Serani, O, Laprévote, G, Massiot, C, Lavaud   +7 more
openaire   +2 more sources

Natural Bioactive New Withanolides

Mini-Reviews in Medicinal Chemistry, 2020
Withanolides are a group of highly oxygenated steroids derived from a C28 ergostane skeleton, and have attracted significant scientific interest due to their complex structural features and multiple bioactivities. More than 170 new natural withanolides were isolated and identified in the last 5 years.
Qian-Qian, Xu, Kui-Wu, Wang
openaire   +2 more sources